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Cannabidiol regulates the expression of hypothalamus-pituitary-adrenal axis-related genes in response to acute restraint stress.

J Psychopharmacol. 2018 Oct 16:269881118805495. doi: 10.1177/0269881118805495. [Epub ahead of print] Viudez-Martínez A1, García-Gutiérrez MS1,2, Manzanares J1,2. Author information Abstract BACKGROUND: Research interest has grown around the potential therapeutic use of cannabidiol in mood-related disorders, due to its anxiolytic and antidepressant-like effects. These have been partially attributed to its action as an allosteric modulator of […]

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Medical Marijuana for Chronic Pain.

CLINICAL DECISIONS Lisa Caulley, M.D., M.P.H., Benjamin Caplan, M.D., and Edgar Ross, M.D. Article Comments open through October 16, 2019 Case Vignette A Woman with Chronic PainLisa Caulley, M.D., M.P.H.Ms. Rothstein is a 31-year-old woman who comes to your office to consult with you regarding a long-standing history of complex regional pain syndrome in her right […]

PM 2 site 207

Adolescent arrestees detained in police cells: an observational study in the Paris, France, area.

Int J Legal Med. 2018 Oct 15. doi: 10.1007/s00414-018-1942-1. [Epub ahead of print] Coudert C1, Vidal C1, Lefèvre T1,2, Chariot P3,4. Author information Abstract OBJECTIVE: Custody conditions in police cells are often demeaning and considered inappropriate for human beings. The detention of young adolescents in police custody has received little attention. Our study aimed to […]

PM 2 site 207

[Limited evidence for therapy with medical cannabis in patients with bipolar disorder].

Ugeskr Laeger. 2018 Oct 15;180(42). pii: V01180046. [Article in Danish] Blach Bentsen MP1, Vinberg M. Author information Abstract There is an increased interest among patients with bipolar disorder for using medical cannabis. The aim of this review was to elucidate, whether medical cannabis has a potential role in the treatment of bipolar disorder. Only one […]

PM 2 site 207

13-loci STR multiplex system for Brazilian seized samples of marijuana: individualization and origin differentiation.

Int J Legal Med. 2018 Oct 15. doi: 10.1007/s00414-018-1940-3. [Epub ahead of print] Fett MS1,2, Mariot RF3, Avila E2,4, Alho CS4, Stefenon VM5, de Oliveira Camargo FA1. Author information Abstract It is known that Cannabis in Brazil could either originate from Paraguay or be cultivated in Brazil. While consumer markets in the North and Northeast […]

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Watching Canada’s experiment with legal cannabis

Editorial Diane Kelsall CMAJ October 15, 2018 190 (41) E1218; DOI: Article Responses Metrics PDF On Oct. 17, 2018, the government of Canada will launch a national, uncontrolled experiment in which the profits of cannabis producers and tax revenues are squarely pitched against the health of Canadians. When Bill C-45 comes into force in […]

PM 2 site 207

New Methods for the Comprehensive Analysis of Bioactive Compounds in Cannabis sativa L. (hemp).

Molecules. 2018 Oct 14;23(10). pii: E2639. doi: 10.3390/molecules23102639. Pellati F1, Brighenti V2, Sperlea J3,4, Marchetti L5, Bertelli D6, Benvenuti S7. Author information Abstract Cannabis sativa L. is a dioecious plant belonging to the Cannabaceae family. The main phytochemicals that are found in this plant are represented by cannabinoids, flavones, and terpenes. Some biological activities of […]

PM 2 site 207

Structure-Based Identification of Potent Natural Product Chemotypes as Cannabinoid Receptor 1 Inverse Agonists.

Molecules. 2018 Oct 13;23(10). pii: E2630. doi: 10.3390/molecules23102630. Pandey P1, Roy KK2,3, Liu H4, Ma G5, Pettaway S6, Alsharif WF7, Gadepalli RS8, Rimoldi JM9,10, McCurdy CR11,12, Cutler SJ13,14, Doerksen RJ15,16. Author information Abstract Natural products are an abundant source of potential drugs, and their diversity makes them a rich and viable prospective source of bioactive […]

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Cannabis use and non-cancer chronic pain

CORRESPONDENCE| VOLUME 3, ISSUE 10, PE468, OCTOBER 01, 2018 Cannabis use and non-cancer chronic pain Download PDF [32 KB] Save Share Reprints Request Top Alex Bekker Open AccessPublished:October, 2018DOI: PlumX Metrics References Article Info Linked Article I read with interest the Article by Gabrielle Campbell and colleagues.1 The authors should be commended on completion of this […]

PM 2 site 207

Cannabidiol presents an inverted U-shaped dose-response curve in a simulated public speaking test.

Rev Bras Psiquiatr. 2018 Oct 11. pii: S1516-44462018005007102. doi: 10.1590/1516-4446-2017-0015. [Epub ahead of print] Linares IM1, Zuardi AW1,2, Pereira LC3, Queiroz RH2,3, Mechoulam R4, Guimarães FS2,5, Crippa JA1,2. Author information Abstract OBJECTIVE: Cannabidiol (CBD), one of the non-psychotomimetic compounds of Cannabis sativa, causes anxiolytic-like effects in animals, with typical bell-shaped dose-response curves. No study, however, […]