Archive by Author

Cannabidiol inhibits endocannabinoid signaling in autaptic hippocampal neurons.

Mol Pharmacol. 2018 Apr 18. pii: mol.118.111864. doi: 10.1124/mol.118.111864. [Epub ahead of print] Straiker A1, Dvorakova M2, Zimmowitch A2, Mackie KP2. Author information Abstract Δ9-THC and cannabidiol (CBD) are two main cannabinoid constituents of marijuana and hashish. The pharmacology of Δ9-THC has been extensively studied, while our understanding of the pharmacology of CBD has remained […]

Cannabinoid Receptor Type 1 Expression in the Developing Avian Retina: Morphological and Functional Correlation With the Dopaminergic System.

Front Cell Neurosci. 2018 Mar 12;12:58. doi: 10.3389/fncel.2018.00058. eCollection 2018. da Silva Sampaio L1, Kubrusly RCC2, Colli YP1, Trindade PP1, Ribeiro-Resende VT1, Einicker-Lamas M3, Paes-de-Carvalho R4, Gardino PF1, de Mello FG1, De Melo Reis RA1. Author information Abstract The avian retina has been used as a model to study signaling by different neuro- and gliotransmitters. […]

Medical Marijuana Use in Older Adults.

J Am Geriatr Soc. 2018 Apr 18. doi: 10.1111/jgs.15346. [Epub ahead of print] Briscoe J1, Casarett D1. Author information Abstract Symptom management in older adults, including pain and distressing non-pain symptoms, can be challenging. Medications can cause side effects that worsen quality of life or create other symptoms, and polypharmacy itself can be detrimental in […]

Medical Marijuana Users are More Likely to Use Prescription Drugs Medically and Nonmedically.

J Addict Med. 2018 Apr 17. doi: 10.1097/ADM.0000000000000405. [Epub ahead of print] Caputi TL1, Humphreys K. Author information Abstract OBJECTIVES: Previous studies have found a negative population-level correlation between medical marijuanaavailability in US states, and trends in medical and nonmedical prescription drug use. These studies have been interpreted as evidence that use of medical marijuana […]

Does Medical Cannabis Use Increase or Decrease the Use of Opioid Analgesics and Other Prescription Drugs?

J Addict Med. 2018 Apr 17. doi: 10.1097/ADM.0000000000000404. [Epub ahead of print] Bachhuber MA1, Arnsten JH, Cunningham CO, Sohler N. Author information Abstract : In observational and retrospective studies, people who use cannabis are more likely than people who do not use cannabis to also use other drugs. People who take medical cannabis are also […]

Dentification and quantification of quercetin, a major consitituent of artocarpus altilis by targeting related genes of apoptosis and cell cycle: in vitro cytotoxic activity against human lung carcinoma cell lines (A549).

Curr Med Chem. 2018 Apr 17. doi: 10.2174/0929867325666180417165247. [Epub ahead of print] Russo S1, De Azevedo WF1. Author information Abstract BACKGROUND: Cannabinoid Receptor 1 (CB1) is a membrane protein prevalent in the central nervous system, whose crystallographic structure has recently been solved. Studies will be needed to investigate CB1 complexes with its ligands and its […]

Positron emission tomography imaging of cerebral glucose metabolism and type 1 cannabinoid receptor availability during temporal lobe epileptogenesis in the amygdala kindling model in rhesus monkeys.

Epilepsia. 2018 Apr 17. doi: 10.1111/epi.14059. [Epub ahead of print] Cleeren E1,2, Casteels C3,4, Goffin K3,4, Koole M3,4, Van Laere K3,4, Janssen P1, Van Paesschen W2. Author information Abstract OBJECTIVE: We investigated changes in the endocannabinoid system and glucose metabolism during temporal lobe epileptogenesis. METHODS: Because it is rarely possible to study epileptogenesis in humans, […]

Faces of Cannabis, Manitoba; Walter Leslie

Introducing a very green Canadian born in Vancouver, British Columbia; welder, Soapstone Carver, Winnipeg Jets fan, loveable family man blessed with 6 children, 22 grandkids and 3 great grandkids. This former Liberal Party delegate, who actively participated in Hemp legalization and the Global Days against the Drug War was involved in Winnipeg’s first ever planned 4/20 event, […]