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The rise and fall of anandamide: processes that control synthesis, degradation, and storage

By March 13, 2021March 22nd, 2021No Comments
Anandamide is known to be involved in sleeping and eating patterns as well as pleasure enhancement and pain relief.
Review

doi: 10.1007/s11010-021-04121-5.

Online ahead of print.
Affiliations 

Abstract

Anandamide is an endocannabinoid derived from arachidonic acid-containing membrane lipids and has numerous biological functions. Its effects are primarily mediated by the cannabinoid receptors CB1 and CB2, and the vanilloid TRPV1 receptor. Anandamide is known to be involved in sleeping and eating patterns as well as pleasure enhancement and pain relief. This manuscript provides a review of anandamide synthesis, degradation, and storage and hence the homeostasis of the anandamide signaling system.

 

Keywords: Anandamide, Endocannabinoid, N-acyltransferase, Phosphatase, Phospholipase

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References

    1. Devane WA, Hanus L, Breuer A, Pertwee RG, Stevenson LA, Griffin G, Gibson D, Mandelbaum A, Etinger A, Mechoulam R (1992) Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258:1946–1949. https://doi.org/10.1126/science – DOI
    1. Maccarrone M (2017) Metabolism of the endocannabinoid anandamide: open questions after 25 years. Front Mol Neurosci 10:166. https://doi.org/10.3389/fnmol.2017.00166 – DOI – PubMed – PMC
    1. Marsicano G, Chaouloff F (2011) Moving bliss: a new anandamide transporter. Nat Neurosci 15:5–6. https://doi.org/10.1038/nn.3011 – DOI – PubMed
    1. Mechoulam R, Parker LA (2013) The endocannabinoid system and the brain. Annu Rev Psychol 64:21–47. https://doi.org/10.1146/annurev-psych-113011-143739 – DOI – PubMed
    1. Ross RA (2003) Anandamide and vanilloid TRPV1 receptors. Br J Pharmacol 140:790–801. https://doi.org/10.1038/sj.bjp.0705467 – DOI – PubMed – PMC

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