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Canna~Fangled Abstracts

Dramatic efficacy of cannabidiol on refractory chronic pain in an adolescent with sickle cell disease

By August 4, 2023August 7th, 2023No Comments

. 2023 Aug 4.

doi: 10.1002/ajh.27049.

Online ahead of print.
Lara Mayrand 1 2 3, Anne-Laure Tarbé de Saint Hardouin 3, Thiago Trovati Maciel 1 4, Rachel Rignault-Bricard 1 4, Melissa Taylor 2 4, Joséphine Brice 2 4, Mariane de Montalembert 2 4, Olivier Hermine 1 4 5 6, Céline Greco 1 3, Slimane Allali 1 2 4
Affiliations 

Abstract

Here, we report a dramatic efficacy of cannabidiol in an adolescent with SCD suffering from chronic pain refractory to other analgesics, with complete regression of chronic pain and rapid plasma histamine level normalization after treatment.

References

REFERENCES

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    1. Allali S, Lionnet F, Mattioni S, et al. Plasma histamine elevation in a large cohort of sickle cell disease patients. Br J Haematol. 2019;186(1):125-129.
    1. Wagner MC, Eckman JR, Wick TM. Histamine increases sickle erythrocyte adherence to endothelium. Br J Haematol. 2006;132(4):512-522.
    1. Rossignol J, Hatton S, Ridley A, Hermine O, Greco C. The effectiveness and safety of pharmaceutical-grade Cannabidiol in the treatment of Mastocytosis-associated pain: a pilot study. Biomedicine. 2023;11(2):520.
    1. Cherukury HM, Argueta DA, Garcia N, et al. Cannabidiol attenuates hyperalgesia in a mouse model of sickle cell disease. Blood. 2023;141(2):203-208.

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