[Epub ahead of print]Suppression of lithium chloride-induced conditioned gaping (a model of nausea-induced behaviour) in rats (using the taste reactivity test) with metoclopramide is enhanced by cannabidiolic acid.
Source
Department of Psychology, University of Guelph, Guelph, ON, Canada.
Abstract
We aimed to determine the potential of various doses of metoclopramide (MCP, a dopamine antagonist) to reduce lithium chloride (LiCl)-induced conditioned gaping (a nausea-induced behaviour) in rats, using the taste reactivity test We then evaluated whether an ineffective low dose ofcannabidiolic acid (CBDA, 0.1μg/kg, Rock et al., 2013), the potent acidic precursor of cannabidiol (CBD, a non-psychoactive component of cannabis) could enhance the anti-nausea effects of an ineffective low dose of MCP. MCP (3.0mg/kg) reduced conditioned gaping responses. Coadministration of ineffective doses of MCP (0.3mg/kg) and CBDA (0.1μg/kg) enhanced the suppression of conditioned gaping, over that of either drug alone, without interfering with conditioned taste avoidance. MCP dose-dependently reduced nausea-induced conditioned gaping in rats. As well the suppression of conditioned gaping was enhanced when ineffective doses of MCP and CBDA were coadministered. These data suggest that CBDA could be a powerful adjunct treatment to anti-emetic regimens for chemotherapy-induced nausea.
© 2013.
© 2013.
KEYWORDS:
5-HT, 5-HT(1A), 5-HT(3), 5-HT1A, 5-hydroxytryptamine, 5-hydroxytryptamine(1A), 5-hydroxytryptamine(3), CBD, CBDA, D(2), DA, LiCl, MCP, OND, SAL, VEH, cannabidiol, cannabidiolic acid, conditioned gaping, dopamine, dopamine(2), i.p., i.v., intraperitoneally, intravenously, lithium chloride, metoclopramide, nausea, ondansetron, s.c., saline, subcutaneously, taste reactivity, vehicle
- PMID:
- 24012649
- [PubMed – as supplied by publisher]
