Endocannabinoids and their attending cannabinoid type 1 (CB₁) receptor have been implicated in animal models of post-traumatic stress disorder (PTSD). However, their specific role has not been studied in people with PTSD. Herein, we present an in vivo imaging study using positron emission tomography (PET) and the CB₁-selective radioligand [¹¹C]OMAR in individuals with PTSD, and healthy controls with lifetime histories of trauma (trauma-exposed controls (TC)) and those without such histories (healthy controls (HC)). Untreated individuals with PTSD (N=25) with non-combat trauma histories, and TC (N=12) and HC (N=23) participated in a magnetic resonance imaging scan and a resting PET scan with the CB₁ receptor antagonist radiotracer [¹¹C]OMAR, which measures the volume of distribution (V_T) linearly related to CB₁ receptor availability. Peripheral levels of anandamide, 2-arachidonoylglycerol, oleoylethanolamide, palmitoylethanolamide and cortisol were also assessed. In the PTSD group, relative to the HC and TC groups, we found elevated brain-wide [¹¹C]OMAR V_T values (F(2,53)=7.96, P=0.001; 19.5% and 14.5% higher, respectively), which were most pronounced in women (F(1,53)=5.52, P=0.023). Anandamide concentrations were reduced in the PTSD relative to the TC (53.1% lower) and HC (58.2% lower) groups. Cortisol levels were lower in the PTSD and TC groups relative to the HC group. Three biomarkers examined collectively-OMAR V_T, anandamide and cortisol-correctly classified nearly 85% of PTSD cases. These results suggest that abnormal CB₁ receptor-mediated anandamide signaling is implicated in the etiology of PTSD, and provide a promising neurobiological model to develop novel, evidence-based pharmacotherapies for this disorder.Molecular Psychiatry advance online publication, 14 May 2013; doi:10.1038/mp.2013.61.

PMID:

 

23670490

 

[PubMed – as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/23670490