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Canna~Fangled Abstracts

Intrahypothalamic injection of cannabidiol increases the extracellular levels of adenosine in nucleus accumbens in rats.

By May 3, 2014No Comments
 2014 May 3. pii: S0168-0102(14)00071-6. doi: 10.1016/j.neures.2014.04.006. [Epub ahead of print]

pm8Intrahypothalamic injection of cannabidiol increases the extracellular levels of adenosine in nucleus accumbens in rats.

Abstract

Cannabidiol (CBD) is a constituent of Cannabis sativa that promotes wakefulness as well as enhances endogenous levels of wake-related neurotransmitters, including dopamine. However, at this date, the effects of CBD on the sleep-inducing molecules, such as adenosine (AD), are unknown. Here, we report that intrahypothalamic injection of CBD (10μg/1μL) increases the extracellular levels of AD collected from nucleus accumbens. Furthermore, the pharmacodynamic of this drug shows that effects on the contents of AD last 2h post-injection. These preliminary findings suggest that CBD promotes the endogenous accumulation of AD.
Copyright © 2014. Published by Elsevier Ireland Ltd.

KEYWORDS:

Adenosine, HPLC, Hypothalamus, Microdialysis, Wakefulness.

PMID:

 24800644
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