Canna~Fangled Abstracts

Accuracy of Self-reported Prescribed Analgesic Medication Use: Linkage between the Quebec Pain Registry and the Quebec Administrative Prescription Claims Databases.

By April 28, 2015 No Comments
 2015 Apr 28. [Epub ahead of print]



The validity of studies conducted with patient registries depends on the accuracy of the self-reported clinical data. As of now, studies about the validity of self-reported use of analgesics among chronic pain populations are scarse. The objective of this study was to assess the accuracy of self-reported prescribed analgesic medication use. This was attained by comparing the data collected in the Quebec Pain Registry (QPR) database to those contained in the Quebec administrative prescription claims database (Régie de l’assurance maladie du Québec [RAMQ]).


To achieve the linkage between the QPR and the RAMQ databases, the first 1,285 patients who were consecutively enrolled in the QPR between October 31 2008 and January 27 2010 were contacted by mail and invited to participate in a study in which they had to provide their unique RAMQ health insurance number. Using RAMQ prescription claims as the reference standard, kappa coefficients, sensitivity, specificity, and their respective 95% confidence intervals were calculated for each therapeutic class of prescribed analgesic drugs that the participants reported taking currently and in the past 12 months.


A total of 569 QPR patients responded to the postal mailing, provided their unique health insurance number, and gave informed consent for the linkage (response proportion=44%). Complete RAMQ prescription claims over the 12 months prior to patient enrolment into the QPR were available for 272 patients, who constituted our validation study population. Regarding current self-reported prescribed analgesic use, Kappa coefficients measuring agreement between the two sources of information ranged from 0.66 to 0.78 for COX-2 selective NSAIDs, anticonvulsants, antidepressants, skeletal muscle relaxants, synthetic cannabinoids, opiate agonists/partial agonists/antagonists, and antimigraine agents therapeutic classes. For the past 12-month self-reported prescribed analgesic use, QPR patients were less accurate regarding anticonvulsants (kappa=0.59), opiate agonists/partial agonists/antagonists (kappa=0.57), and antimigraine agents use (kappa=0.39).


Information about current prescribed analgesic medication use as reported by chronic pain patients was accurate for the main therapeutic drug classes used in chronic pain management. Accuracy of the past year self-reported prescribed analgesic use was somewhat lower but only for certain classes of medication, the concordance being good on all the others.





[PubMed – as supplied by publisher]
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