Canna~Fangled Abstracts

Cannabinoid Receptor 2 Activation Restricts Fibrosis and Alleviates Hydrocephalus after Intraventricular Hemorrhage.

By October 18, 2016 No Comments
2016 Oct 18. pii: S0006-8993(16)30719-3. doi: 10.1016/j.brainres.2016.10.016. [Epub ahead of print]
Tan Q1, Chen Q1, Feng Z1, Shi X2, Tang J1, Tao Y1, Jiang B1, Tan L1, Feng H1, Zhu G1, Yang Y3, Chen Z4.

Abstract

pm-2-site-207Fibrosis in ventricular system has a role in hydrocephalus following intraventricular hemorrhage (IVH). The cannabinoid receptor 2 (CB2) has been reported to participate in alleviating the fibrosis process of many diseases. However, its role in fibrosis after IVH was unclear so far, and we hypothesized that CB2 activation has potential to attenuate hydrocephalus after IVH via restricting fibrosis. So the present study was designed to investigate this hypothesis in a modified rat IVH model. Autologous non-anticoagulative blood injection model was induced to mimic ventricular extension of hemorrhage in adult Sprague-Dawley rats. Rats were randomized to receive JWH-133(CB2 agonist), SR144528 (CB2 antagonist) or saline. The lateral ventricular volumes, fibrosis in the subarachnoid space and ventricular wall, transforming growth factor-β 1(TGF-β1) in cerebrospinal fluid and brain tissue, and animal neurological scores were measured to evaluate the effects of CB2 in hydrocephalus following IVH. CB2 agonist JWH-133 significantly decreased the lateral ventricular volumes, improved the associated neurological deficits, down-regulated TGF-β1 expression, and alleviated fibrosis in the subarachnoid space and ventricular wall after IVH. All of these effects were reversed by SR144528. In conclusion, CB2 may have anti-fibrogenic effects after IVH. CB2 agonist suppressed fibrosis of ventricular system and alleviated hydrocephalus following IVH, which is partly mediated by inhibiting TGF-β1.

KEYWORDS:

Cannabinoid receptor 2; Fibrosis; Hydrocephalus; Intracerebral hemorrhage; Intraventricular hemorrhage; Transforming growth factor-β 1

PMID: 27769788

 

DOI: 10.1016/j.brainres.2016.10.016
[PubMed – as supplied by publisher]
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