Cannabinoids suppress acute and anticipatory nausea in pre-clinical rat models of conditioned gaping.

The sensation of nausea is one of the most debilitating human experiences. Current anti-emetic therapies are effective in reducing vomiting, but are less effective in reducing acute and delayed nausea and are completely ineffective in reducing anticipatory nausea. Recent pre-clinical evidence using a selective rat model of nausea (conditioned gaping reactions) has revealed that cannabinoids have great promise as treatments for nausea and that their anti-nausea effects may be mediated by the interoceptive insular cortex. This article is protected by copyright. All rights reserved.
© 2015 American Society for Clinical Pharmacology and Therapeutics.