Cannabinomimetric Lipids: From Natural Extract to Artificial Synthesis.

Endocannabinoid system is related with various physiological and cognitive processes including fertility, pregnancy, during pre- and postnatal development, pain-sensation, mood, appetite, and memory. In the latest decades, an important milestone concerning the endocannabinoid system was the discovery of the existence of the cannabinoid receptors CB₁ and CB₂. Anandamide was the first reported endogenous metabolite, which adjusted the release of some neurotransmitters through binding to the CB₁ or CB₂ receptors. Then a series of cannabinomimetric lipids were extracted from marine organisms, which possessed similar structure with anandamide. This review will provide a short account about cannabinomimetric lipids for their extraction and synthesis.