Combined inhibition of FAAH and COX produces enhanced anti-allodynic effects in mouse neuropathic and inflammatory pain models.
Abstract
PERSPECTIVE:
Tandem inhibition of FAAH and COX attenuates inflammatory and neuropathic pain states, which may avoid potentially harmful side effects of other therapeutic options, such as NSAIDs or opioids.
Copyright © 2014. Published by Elsevier Inc.
KEYWORDS:
anandamide; cyclooxygenase (COX); endogenous cannabinoid (endocannabinoid); fatty acid amide hydrolase; inflammatory pain; neuropathic pain; prostaglandins
- PMID:
- 25058512
- [PubMed – as supplied by publisher]