2015 Jan 13. doi: 10.1002/ardp.201400201. [Epub ahead of print]
Espinosa-Bustos C1, Lagos CF, Romero-Parra J, Zárate AM, Mella-Raipán J, Pessoa-Mahana H, Recabarren-Gajardo G, Iturriaga-Vásquez P, Tapia RA, Pessoa-Mahana CD.
Abstract
A series of N-acyl-2,5-dimethoxyphenyl-1H-benzimidazoles were designed based on a CoMFA model for cannabinoid receptor type 1 (CB1) ligands. Compounds were synthesized and radioligand binding affinity assays were performed. Eight novel benzimidazoles exhibited affinity for the CB1 receptor in the nanomolar range, and the most promising derivative compound 5 displayed a Ki value of 1.2 nM when compared to CP55,940. These results confirm our previously reported QSAR model on benzimidazole derivatives, providing new information for the development of small molecules with high CB1 affinity.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
KEYWORDS:
Benzimidazole derivatives; Binding affinity; Cannabinoid receptor type 1; CoMFA; Molecular modeling
- PMID:
- 25641513
- [PubMed – as supplied by publisher]