Canna~Fangled Abstracts

Evaluation of the role of the cannabidiol system in an animal model of ischemia/reperfusion kidney injury.

By December 27, 2015 No Comments
2015 Dec;27(4):383-389.
[Article in English, Portuguese]

Abstract

OBJECTIVE:

PM 1aThis work aimed to investigate the effects of the administration of cannabidiol in a kidney ischemia/reperfusion animal model.

METHODS:

Kidney injury was induced by 45 minutes of renal ischemia followed by reperfusion. Cannabidiol (5mg/kg) was administered immediately after reperfusion.

RESULTS:

Ischemia/reperfusion increased the IL-1 and TNF levels, and these levels were attenuated by cannabidiol treatment. Additionally, cannabidiol was able to decrease lipid and protein oxidative damage, but not the nitrite/nitrate levels. Kidney injury after ischemia/reperfusion seemed to be independent of the cannabidiol receptor 1 and cannabidiol receptor 2 (CB1 and CB2) expression levels, as there was no significant increase in these receptors after reperfusion.

CONCLUSION:

The cannabidiol treatment had a protective effect against inflammation and oxidative damage in the kidney ischemia/reperfusion model. These effects seemed to be independent of CB1/CB2 receptor activation.

PMID:

 

26761477

 

[PubMed – as supplied by publisher]
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