Canna~Fangled Abstracts

Flavonoid-induced autophagy in hormone sensitive breast cancer cells.

By September 8, 2009 No Comments
 2009 Sep;80(6):327-32. doi: 10.1016/j.fitote.2009.04.002. Epub 2009 Apr 14.

pm8Flavonoid-induced autophagy in hormone sensitive breast cancer cells.

Abstract

The activity of 8-prenylapigenin (8-PA) and its 3′-methoxylated analogue isocannflavin B (IsoB) was investigated in estrogen-dependent T47-D and estrogen-independent MDA-MB-231 human breast cancer cell lines. 8-PA showed a biphasic effect on T47-D cell proliferation, while no significant effect was observed on MDA-MB-231 cells. Conversely, IsoB exhibited only an inhibitory effect on T47-D cell proliferation, accompanied by the appearance of an intense intracytoplasmic vacuolization of autophagic origin. Moreover, biochemical analysis showed that IsoB reduced Akt phosphorylation and p21(Cip1) expression in T47-D cells. These data show that the prenylflavone moiety is a versatile platform for the induction and modulation of bioactivity.
PMID:
19371773
[PubMed – indexed for MEDLINE]

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elsevier logo croppedGraphical abstract

Estrogenic activity of 8-prenylnaringenin (8-PN, 1) is well documented. Here we investigate the biological activity of the prenylated flavone 8-prenylapigenin (8-PA, 2b) and its 3′-methoxylated analogue isocannflavin B (IsoB, 2a).

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Keywords

  • 8-Prenylapigenin;
  • 8-Prenylnaringenin;
  • Isocannflavin B;
  • Breast cancer cells;
  • Cell signalling;
  • Autophagy
Corresponding author contact information
Corresponding author. Tel.: +39 0321 375820; fax: +39 0321 375821.

Copyright © 2009 Elsevier B.V. All rights reserved.
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