Canna~Fangled Abstracts

In vivo effects of cannabinoids on macromolecular biosynthesis in Lewis lung carcinomas.

By April 20, 1977 No Comments
1977;2(2):51-4.

In vivo effects of cannabinoids on macromolecular biosynthesis in Lewis lung carcinomas.

Abstract

pm1Cannabinoids represent a novel class of drugs active in increasing the life span mice carrying Lewis lung tumors and decreasing primary tumor size. In the present studies, the effects of delta9-THC, delta8-THC, and cannabidiol on tumor macromolecular biosynthesis were studied. These drugs inhibit thymidine-3H incorporation into DNA acutely, but did not inhibit leucine uptake into tumor protein. At 24 h after treatment, cannabinoids did not inhibit thymidine-3H incorporation into DNA, leucine-3H uptake into protein or cytidine-3H into RNA.
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