In vivo effects of cannabinoids on macromolecular biosynthesis in Lewis lung carcinomas.
Cannabinoids represent a novel class of drugs active in increasing the life span mice carrying Lewis lung tumors and decreasing primary tumor size. In the present studies, the effects of delta9-THC, delta8-THC, and cannabidiol on tumor macromolecular biosynthesis were studied. These drugs inhibit thymidine-3H incorporation into DNA acutely, but did not inhibit leucine uptake into tumor protein. At 24 h after treatment, cannabinoids did not inhibit thymidine-3H incorporation into DNA, leucine-3H uptake into protein or cytidine-3H into RNA.
- [PubMed – indexed for MEDLINE]
- DNA, Neoplasm/biosynthesis*
- Lung Neoplasms/drug therapy*
- Lung Neoplasms/metabolism
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Neoplasm Proteins/biosynthesis*
- Neoplasms, Experimental/drug therapy
- RNA, Neoplasm/biosynthesis*
- Tissue Distribution