To the Editor Dr Whiting and colleagues presented a systematic review of medical cannabinoids.1 The University of California Center for Medicinal Cannabis Research has conducted 5 placebo-controlled clinical trials with smoked or inhaled cannabis for neuropathic pain, representing, to my knowledge, the only studies approved by the US Department of Health and Human Services to be conducted in the United States during the past 2 decades.
Comment & Response II
JAMA. 2015;314(16):1751. doi:10.1001/jama.2015.11435.
To the Editor Dr Whiting and colleagues1 presented the results of a systematic review and meta-analysis of medical cannabinoids, claiming moderate-quality evidence supporting their use for chronic pain and spasticity. The studies on which they relied included investigations of numerous preparations with varying routes of administration. The products considered each have their own unique pharmacodynamics.
