2014 Nov 7;25(1):88-91. doi: 10.1016/j.bmcl.2014.11.003. [Epub ahead of print]
Novel azoles as potent and selective cannabinoid CB2 receptor agonists.
Harnett JJ1, Dolo C2, Viossat I3, Auger F4, Ferrandis E5, Bigg D2, Auguet M5, Auvin S2, Chabrier PE5.
Abstract
Novel azole compounds were prepared which demonstrated potent hCB2 binding activities with antioxidant activity for a selected compound. These compounds show good selectivity over the hCB1 receptor and are full agonists at the hCB2 receptor.
Copyright © 2014 Elsevier Ltd. All rights reserved.
Copyright © 2014 Elsevier Ltd. All rights reserved.
KEYWORDS:
Antioxidants; Cannabinoid agonists; Chimeric molecules; Dual acting molecules; Human CB2 agonists; Synthesis
- PMID:
25466197
[PubMed – as supplied by publisher]
