2015 Oct 1;43(5):1122-1126.
Salazar M1, Lorente M1, Orea-Soufi A1, Dávila D1, Erazo T2, Lizcano J2, Carracedo A3, Kiss-Toth E4, Velasco G5.
Abstract
Tribbles pseudokinase 3 (TRIB3) belongs to the tribbles family of pseudokinases. In this article, we summarize several observation obtained by our laboratories supporting that TRIB3 plays a crucial role in the anti-cancer activity of cannabinoids (a novel family of potential anti-cancer agents derived from marijuana) and that TRIB3 genetic inactivation enhances cancer generation and progression.© 2015 Authors; published by Portland Press Limited.
KEYWORDS:
animal models of cancer; autophagy; cannabinoids; endoplasmic reticulum (ER) stress; tribbles pseudokinases
- PMID:
- 26517935
- [PubMed – as supplied by publisher]
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