Orphan G protein receptor GPR55 as an emerging target in cancer therapy and management.
Source
Digestive Disease Research Center, Scott and White Hospital, Temple, TX, USA ; Department of Internal MedicineTexas A&M Health Science Center, Temple, TX, USA ; Research Service, Central Texas Veterans Health Care System, Temple, TX, USA.
Abstract
G protein-coupled receptors (GPCRs) modulate a vast array of cellular processes. The current review gives an overview of the general characteristics of GPCRs and their role in physiological conditions. In addition, it describes the current knowledge of the physiological and pathophysiological functions of GPR55, an orphan GPCR, and how it can be exploited as a therapeutic target to combat various cancers.
KEYWORDS:
GPCR, GPR55, cancer, endocannabinoids
- PMID:
23869178
[PubMed]
