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Canna~Fangled Abstracts

Pd-Catalyzed C-H Lactonization for Expedient Synthesis of Biaryl Lactones and Total Synthesis of Cannabinol.

By May 15, 2013No Comments

Pub Med

 [Epub ahead of print]

 

Pd-Catalyzed C-H Lactonization for Expedient Synthesis of Biaryl Lactones and Total Synthesis of Cannabinol.

 

 

Source

Department of Chemistry, University of Science and Technology of China , 96 Jinzhai Road, Hefei, Anhui 230026, China.

 

Abstract

Abstract ImageA practical Pd(II)/Pd(IV)-catalyzed carboxyl-directed C-H activation/C-O cyclization to construct biaryl lactones has been developed. The synthetic utility of this new reaction was demonstrated in an atom-economical and operationally convenient total synthesis of the natural product cannabinol from commercially available starting materials, with the newly developed method used for two key steps.

 

PMID:

 23662848
[PubMed – as supplied by publisher]prisoner of the system2http://www.ncbi.nlm.nih.gov/pubmed/23662848