Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2017 Mar 28;42(3):340-345. doi: 10.11817/j.issn.1672-7347.2017.03.017.
[Article in Chinese; Abstract available in Chinese from the publisher]
Neuropathic pain is a class of pain caused by an injury or diseases of the somatosensory system and characterized by spontaneous pain, allodynia, and hyperalgesia. It is well established that central sensitization is one of the key mechanisms underlying the development and maintenance of neuropathic pain. Cannabinoid receptor 1 (CB1R) of endocannabinoid system modulates synaptic transmission, regulates synaptic plasticity, inhibits central sensitization, and thus attenuates neuropathic pain. Recent studies have shown that activation of CB1R also involves in the relief of neuropathic pain-induced depression.