Cell Metab. 2017 Jan 10;25(1):8-10. doi: 10.1016/j.cmet.2016.12.020.
Harkany T1, Horvath TL2.
Abstract
Classical views posit G protein-coupled cannabinoid receptor 1s (CB1Rs) at the cell surface with cytosolic Giα-mediated signal transduction. Hebert-Chatelain et al. (2016) instead place CB1Rs at mitochondria limiting neuronal respiration by soluble adenylyl cyclase-dependent modulation of complex I activity. Thus, neuronal bioenergetics link to synaptic plasticity and, globally, learning and memory.
Copyright © 2017 Elsevier Inc. All rights reserved.
KEYWORDS:
GPCR; THC; axonal growth; bioenergetics; cannabinoid; cannabinoid receptor 1; cannabis; endocannabinoid; mitochondrial import; respiration
- PMID: 28076767
- DOI: 10.1016/j.cmet.2016.12.020
- [PubMed – in process]
