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Canna~Fangled Abstracts

The cytokine and endocannabinoid systems are co-regulated by NF-κB p65/RelA in cell culture and transgenic mouse models of Huntington's disease and in striatal tissue from Huntington's disease patients

By December 24, 2013No Comments
J Neuroimmunol. 2013 Dec 12. pii: S0165-5728(13)00339-1. doi: 10.1016/j.jneuroim.2013.12.008. [Epub ahead of print]

pm8The cytokine and endocannabinoid systems are co-regulated by NF-κB p65/RelA in cell culture and transgenic mouse models of Huntington’s disease and in striatal tissue from Huntington’s disease patients.

Abstract

Transcriptional dysregulation is a major pathological feature of Huntington’s disease (HD). The goal of this study was to understand how p65/RelA co-regulated genes, specifically those of the cytokine and endocannabinoid systems, were affected in HD. p65/RelA levels were lower in human HD tissue and R6/2 HD mice, as were the levels of the type 1 cannabinoid receptor (CB1), IL-1β, IL-8, CCL5, GM-CSF, MIP-1β, and TNFα, all of which may be regulated by p65/RelA. Activation of p65/RelA restored CB1 and CCL5 expression in STHdh cell models of HD. Therefore, p65/RelA activation may normalize the expression of some genes in HD.
Copyright © 2013 Elsevier B.V. All rights reserved.

KEYWORDS:

Cannabinoid, Cytokine, Huntington’s disease, NF-κB p65/RelA, Neuroinflammation

PMID:

 24360910
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