Archive | October, 2003

Gamma-irradiation enhances apoptosis induced by cannabidiol, a non-psychotropic cannabinoid, in cultured HL-60 myeloblastic leukemia cells.

2003 Oct;44(10):1767-73. Gamma-irradiation enhances apoptosis induced by cannabidiol, a non-psychotropic cannabinoid, in cultured HL-60 myeloblastic leukemia cells. Gallily R1, Even-Chena T, Katzavian G, Lehmann D, Dagan A, Mechoulam R. Author information Abstract Two non-psychotropic cannabinoids, cannabidiol (CBD) and cannabidiol-dimethylheptyl (CBD-DMH), induced apoptosis in a human acute myeloid leukemia (AML) HL-60 cell line. Apoptosis was determined by staining with bisBenzimide and […]

CB1 cannabinoid receptors and on-demand defense against excitotoxicity.

2003 Oct 3;302(5642):84-8. Marsicano G1, Goodenough S, Monory K, Hermann H, Eder M, Cannich A, Azad SC, Cascio MG, Gutiérrez SO, van der Stelt M, López-Rodriguez ML, Casanova E, Schütz G, Zieglgänsberger W, Di Marzo V, Behl C, Lutz B. Author information Abstract Abnormally high spiking activity can damage neurons. Signaling systems to protect neurons from the consequences of abnormal discharge activity have been postulated. We generated conditional mutant mice that […]

Cannabinoids: potential anticancer agents.

2003 Oct;3(10):745-55. Cannabinoids: potential anticancer agents. Guzmán M. Author information  Abstract Cannabinoids – the active components of Cannabis sativa and their derivatives – exert palliative effects in cancer patients by preventing nausea, vomiting and pain and by stimulating appetite. In addition, these compounds have been shown to inhibit the growth of tumour cells in culture and […]

Neurons on cannabinoids: dead or alive?

Br J Pharmacol. Oct 2003; 140(3): 439–440. Published online Oct 1, 2003. doi:  10.1038/sj.bjp.0705465 PMCID: PMC1574056 Neurons on cannabinoids: dead or alive? Manuel Guzmán1,* Author information ► Article notes ► Copyright and License information ► This article has been cited by other articles in PMC. Preparations from Cannabis sativa (marijuana) have been used for many centuries both medicinally and recreationally. However, the chemical structure of their active components – […]