Archive | May, 2012

Sativex-like combination of phytocannabinoids is neuroprotective in malonate-lesioned rats, an inflammatory model of Huntington’s disease: role of CB1 and CB2 receptors.

ACS Chemical Neuroscience ACS Chem Neurosci. May 16, 2012; 3(5): 400–406.  Published online Feb 9, 2012. doi:  10.1021/cn200114w PMCID: PMC3382456 Sativex-like Combination of Phytocannabinoids is Neuroprotective in Malonate-Lesioned Rats, an Inflammatory Model of Huntington’s Disease: Role of CB1and CB2 Receptors Sara Valdeolivas,†‡§# Valentina Satta,†# Roger G. Pertwee, Javier Fernández-Ruiz,*†‡§ and  Onintza Sagredo*†‡§ Author information ► Article notes ► Copyright and License information ► This article has been cited by other articles […]

The Endocannabinoid System: From Basic Research to Translational Opportunity

ACS Chemical Neuroscience ACS Chem Neurosci. 2012 May 16; 3(5): 337–338.  Published online 2012 May 16. doi:  10.1021/cn3000444 PMCID: PMC3382449 The Endocannabinoid System: From Basic Research to Translational Opportunity Jacqueline L. Blankman and  Benjamin F. Cravatt Author information ► Copyright and License information ► This special issue of ACS Chemical Neuroscience, which was guest-edited by Rao Rapaka, Joni Rutter, and David Shurtleff and relates […]

Long-term treatment with methanandamide attenuates LPS-induced periodontitis in rats.

2012 Sep;61(9):941-8. doi: 10.1007/s00011-012-0485-z. Epub 2012 May 12. Long-term treatment with methanandamide attenuates LPS-induced periodontitis in rats. Ossola CA1, Surkin PN, Pugnaloni A, Mohn CE, Elverdin JC, Fernandez-Solari J. Author information Abstract OBJECTIVE: Evidence exists of the anti-inflammatory and immunological properties of endocannabinoids in various tissues; the aim of the present study was therefore to assess the effect of long-term […]

Biologic Mechanisms of Oral Cancer Pain and Implications for Clinical Therapy

J Dent Res. 2012 May; 91(5): 447–453.  doi:  10.1177/0022034511424156 PMCID: PMC3327727 Biologic Mechanisms of Oral Cancer Pain and Implications for Clinical Therapy C.T. Viet1,2 and  B.L. Schmidt1,2,* Author information ► Article notes ► Copyright and License information ► This article has been cited by other articles in PMC. Go to: ABSTRACT Cancer pain is an ever-present public health concern. With innovations in treatment, cancer patients are […]

Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?

Br J Clin Pharmacol. Feb 2013; 75(2): 323–333. Published online May 25, 2012. doi:  10.1111/j.1365-2125.2012.04341.x PMCID: PMC3579248 Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid? Javier Fernández-Ruiz,1,2,3 Onintza Sagredo,1,2,3 M Ruth Pazos,4 Concepción García,1,2,3 Roger Pertwee,5 Raphael Mechoulam,6 and José Martínez-Orgado4,7 Author information ► Article notes ► Copyright and License information ► This article has been cited by other articles in PMC. Go to: Abstract Cannabidiol (CBD) is a phytocannabinoid with […]

Heat exposure of Cannabis sativa extracts affects the pharmacokinetic and metabolic profile in healthy male subjects.

Heat exposure of Cannabis sativa extracts affects the pharmacokinetic and metabolic profile in healthy male subjects. Eichler M, Spinedi L, Unfer-Grauwiler S, Bodmer M, Surber C, Luedi M, Drewe J. Source Departments of Clinical Pharmacology and Gastroenterology & Hepatology, University Hospital Basel, Petersgraben 4, Basel, Switzerland. Abstract The most important psychoactive constituent of CANNABIS SATIVA L. is Δ (9)-tetrahydrocannabinol (THC). Cannabidiol (CBD), another important constituent, is able […]

Towards the use of cannabinoids as antitumour agents.

2012 May 4;12(6):436-44. doi: 10.1038/nrc3247. Towards the use of cannabinoids as antitumour agents. Velasco G1, Sánchez C, Guzmán M. Author information Abstract Various reports have shown that cannabinoids (the active components of marijuana and their derivatives) can reduce tumour growth and progression in animal models of cancer, in addition to their well-known palliative effects on some cancer-associated […]