Archive | November, 2013

Cannabidiol Promotes Amyloid Precursor Protein Ubiquitination and Reduction of Beta Amyloid Expression in SHSY5YAPP+ Cells Through PPARγ Involvement.

[Epub ahead of print] Cannabidiol Promotes Amyloid Precursor Protein Ubiquitination and Reduction of Beta Amyloid Expression in SHSY5YAPP+ Cells Through PPARγ Involvement. Scuderi C, Steardo L, Esposito G. Source Department of Physiology and Pharmacology ‘Vittorio Erspamer’, SAPIENZA University of Rome, P.le A. Moro, 5, 00185, Rome, Italy. Abstract The amyloidogenic cascade is regarded as a key factor at […]

Translational evidence for the involvement of the endocannabinoid system in stress-related psychiatric illnesses.

 [Epub ahead of print] Translational evidence for the involvement of the endocannabinoid system in stress-related psychiatric illnesses. Hill MN, Patel S. Source Hotchkiss Brain Institute, Departments of Cell Biology & Anatomy and Psychiatry, University of Calgary, 3330 Hospital Drive NW, Calgary AB T2N4N1, Canada. mnhill@ucalgary.ca. Abstract Accumulating evidence over the past decade has highlighted an important role of […]

Secondary Metabolites from Eupenicillium parvum and Their in Vitro Binding Affinity for Human Opioid and Cannabinoid Receptors.

 [Epub ahead of print] Secondary Metabolites from Eupenicillium parvum and Their in Vitro Binding Affinity for Human Opioid and Cannabinoid Receptors. León F, Gao J, Dale OR, Wu Y, Habib E, Husni AS, Hill RA, Cutler SJ. Source Department of Medicinal Chemistry, School of Pharmacy, The University of Mississippi, University, MS, USA. Abstract Phytochemical investigation of the soil microfungus Eupenicillum parvum led to the […]

Does the neuroprotective role of anandamide display diurnal variations?

Does the neuroprotective role of anandamide display diurnal variations? Martinez-Vargas M, Morales-Gomez J, Gonzalez-Rivera R, Hernandez-Enriquez C, Perez-Arredondo A, Estrada-Rojo F,Navarro L. Source Physiology Department, School of Medicine, Universidad Nacional Autonoma de Mexico, AP 70-250, Mexico D.F. 04510, Mexico. lnavarro@unam.mx. Abstract The endocannabinoid system is a component of the neuroprotective mechanisms that an organism displays after traumatic brain injury (TBI). […]

Controlled-Deactivation Cannabinergic Ligands.

[Epub ahead of print] Controlled-Deactivation Cannabinergic Ligands. Sharma R, Nikas SP, Paronis CA, Wood JT, Halikhedkar A, Guo JJ, Thakur GA, Kulkarni S, Benchama O, Raghav JG, Gifford RS, Jarbe TU, Bergman J, Makriyannis A. Abstract We report an approach for obtaining novel cannabinoid analogs with controllable deactivation and improved druggability. Our design involves the incorporation of a metabolically labile ester group at the 2′-position on a series of (-)-D8-THC […]

Cannabinoids and the endocannabinoid system in lower urinary tract function and dysfunction.

 [Epub ahead of print] Cannabinoids and the endocannabinoid system in lower urinary tract function and dysfunction. Hedlund P. Source Urological Research Institute, San Raffaele Scientific Institution, Milan, Italy; Department of Clinical Pharmacology, Linköping, Sweden. Abstract AIMS: To review knowledge on cannabinoids and the endocannabinoid system in lower urinary tract function and dysfunction. METHODS: Review of MEDLINE using defined […]

Synthetic strategies for radioligands for in vivo imaging of brain cannabinoid type-1 receptors.

Synthetic strategies for radioligands for in vivo imaging of brain cannabinoid type-1 receptors. Ahamed M, Verbruggen A, Bormans G. Source Laboratory for Radiopharmacy, IMIR KU Leuven, O&N2, Herestraat 49, Box 821, BE-3000, Leuven, Belgium. Abstract Despite its abundant expression in the brain, the cannabinoid type-1 (CB1) receptor was discovered only in 1988. During the last decade, efforts from several research groups have […]

New strategies in treating male lower urinary tract symptoms.

New strategies in treating male lower urinary tract symptoms. Füllhase C, Soler R, Gratzke C. Source aDepartment of Urology, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany bDivision of Urology, Federal University of São Paulo (RS), São Paulo, Brazil. Abstract PURPOSE OF REVIEW: Improved understanding of the pathogenesis of lower urinary tract symptoms (LUTS) has led to the development of […]

Impact of obesity and bariatric surgery on metabolism and coronary circulatory function.

Impact of obesity and bariatric surgery on metabolism and coronary circulatory function. Valenta I, Dilsizian V, Quercioli A, Jüngling FD, Ambrosio G, Wahl R, Schindler TH. Source Department of Radiology, Johns Hopkins University, Division of Nuclear Medicine, Baltimore, MD, USA. Abstract Increases in intra-abdominal visceral adipose tissue have been widely appreciated as a risk factor for metabolic disorders such as dyslipidemia, […]