Archive | December, 2013

A role for endocannabinoids in acute stress-induced suppression of the hypothalamic-pituitary-gonadal axis in male rats.

2013 Dec;40(4):155-62. doi: 10.5653/cerm.2013.40.4.155. Epub 2013 Dec 31. Clin Exp Reprod Med. 2013 December; 40(4): 155–162. Published online 2013 December 31. doi:  10.5653/cerm.2013.40.4.155 PMCID: PMC3913894 A role for endocannabinoids in acute stress-induced suppression of the hypothalamic-pituitary-gonadal axis in male rats Maryam Karamikheirabad,1 Gila Behzadi,2 Mahdieh Faghihi,1 Reza Raoofian,3 Shahram Ejtemaei Mehr,4 Wieteke Ameliek Zuure,5 and Hamid Reza Sadeghipour1 Author information ► Article notes ► Copyright and License information ► Go to: Abstract […]

Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines.

J Pharmacol Exp Ther. 2004 Mar;308(3):838-45. Epub 2003 Nov 14. Skip to main page content HOME CURRENT ISSUE ARCHIVE FEEDBACK SUBSCRIPTIONS ALERTS HELP Next Section Abstract   Recently, cannabinoids (CBs) have been shown to possess antitumor properties. Because the psychoactivity of cannabinoid compounds limits their medicinal usage, we undertook the present study to evaluate the in […]

Attenuation of experimental autoimmune hepatitis by exogenous and endogenous cannabinoids: involvement of regulatory T cells.

Mol Pharmacol. Author manuscript; available in PMC 2010 February 24. Published in final edited form as: Mol Pharmacol. 2008 July; 74(1): 20–33. Published online 2008 April 3. doi:  10.1124/mol.108.047035 PMCID: PMC2828293 NIHMSID: NIHMS155891 Attenuation of Experimental Autoimmune Hepatitis by Exogenous and Endogenous Cannabinoids: Involvement of Regulatory T Cells Venkatesh L. Hegde, Shweta Hegde, Benjamin F. Cravatt, Lorne J. Hofseth, Mitzi Nagarkatti, andPrakash S. Nagarkatti Author […]

Alterations of endocannabinoids in cerebrospinal fluid of dogs with epileptic seizure disorder.

[Epub ahead of print] Alterations of endocannabinoids in cerebrospinal fluid of dogs with epileptic seizure disorder. Gesell FK, Zoerner AA, Brauer C, Engeli S, Tsikas D, Tipold A. Abstract BACKGROUND: Epilepsy is one of the most common chronic neurological disorders in dogs characterized by recurrent seizures. The endocannabinoid (EC) system plays a central role in suppressing pathologic neuronal excitability and in controlling […]

The Non-Psychoactive Plant Cannabinoid, Cannabidiol Affects Cholesterol Metabolism-Related Genes in Microglial Cells

The Non-Psychoactive Plant Cannabinoid, Cannabidiol Affects Cholesterol Metabolism-Related Genes in Microglial Cells Neta Rimmerman, Ana Juknat, Ewa Kozela, Rivka Levy, Heather B. Bradshaw, Zvi Vogel 3 Citations  Abstract Cannabidiol (CBD) is a non-psychoactive plant cannabinoid that is clinically used in a 1:1 mixture with the psychoactive cannabinoid Δ9-tetrahydrocannabinol (THC) for the treatment of neuropathic pain and […]

A potential role for GPR55 in the regulation of energy homeostasis.

[Epub ahead of print] A potential role for GPR55 in the regulation of energy homeostasis. Simcocks AC1, O’Keefe L1, Jenkin KA1, Mathai ML2, Hryciw DH3, McAinch AJ4. Author information Abstract G protein-coupled receptor 55 (GPR55) is a putative cannabinoid receptor that is expressed in several tissues involved in regulating energy homeostasis, including the hypothalamus, gastrointestinal tract, pancreas, liver, white adipose and skeletal […]

Modulation of Strain-Specific Differences in Gene Expression by Cannabinoid Type 2 Receptor Deficiency.

[Epub ahead of print] Modulation of Strain-Specific Differences in Gene Expression by Cannabinoid Type 2 Receptor Deficiency. Sophocleous A, Sims AH, Idris AI, Ralston SH. Author information Abstract Previous studies have shown that the skeletal consequences of cannabinoid receptor deficiency differ in different strains of mice. In order to explore the mechanisms responsible, we analysed global gene expression in bone from wild-type […]

Concurrent pharmacological modification of cannabinoid-1 and glucagon-like peptide-1 receptor activity affects feeding behavior and body weight in rats fed a free-choice, high-carbohydrate diet.

Concurrent pharmacological modification of cannabinoid-1 and glucagon-like peptide-1 receptor activity affects feeding behavior and body weight in rats fed a free-choice, high-carbohydrate diet. Radziszewska E, Wolak M, Bojanowska E. Author information Abstract To extend preliminary studies on the effects on food intake of the combined use of cannabinoid (CB) 1 and glucagon-like peptide-1 (GLP-1) receptor agonists and antagonists, the effect […]

Endogenous cannabinoid signaling at inhibitory interneurons.

2013 Dec 28;26C:42-50. doi: 10.1016/j.conb.2013.12.006. [Epub ahead of print] Endogenous cannabinoid signaling at inhibitory interneurons. Younts TJ1, Castillo PE2. Author information Abstract Significant progress has been made in our understanding of how endogenous cannabinoids (eCBs) signal at excitatory and inhibitory synapses in the central nervous system (CNS). This review discusses how eCBs regulate inhibitory interneurons, their synapses, and the networks […]

Targeting steroid hormone receptor pathways in the treatment of hormone dependent cancers.

Targeting steroid hormone receptor pathways in the treatment of hormone dependent cancers. Authors Castoria G, Lombardi M, Barone MV, Bilancio A, Di Domenico M, De Falco A, Varricchio L, Bottero D, Nanayakkara M, Migliaccio A, Auricchio F. Journal Curr Pharm Biotechnol. 2004 Oct;5(5):459-70. Affiliation Abstract Sex steroid hormones play a central role in the development […]