Archive | March, 2014

Indiscernible Cannabinoid Science ~ Publius’ March 2014 Roundup, New on the Bryan William Brickner Blog

Indiscernible Cannabinoid Science ~ Publius’ March 2014 Roundup, New on the Bryan William Brickner Blog March’s cannabinoid science roundup on the Bryan William Brickner Blog highlights new National Institutes of Health (PubMed) research. The homeostatic role of the cannabinoid system is the focus with Publius of The Cannabis Papers providing the voice ~ as well […]

18β-glycyrrhetinic acid attenuates anandamide-induced adiposity and high-fat diet induced obesity.

 2014 Mar 31. doi: 10.1002/mnfr.201300763. [Epub ahead of print] 18β-glycyrrhetinic acid attenuates anandamide-induced adiposity and high-fat diet induced obesity. Park M1, Lee JH, Choi JK, Hong YD, Bae IH, Lim KM, Park YH, Ha H. Author information Abstract SCOPE: Previous reports suggest that licorice extract has various metabolically beneficial effects and may help to alleviate adiposity and hyperlipidemia. However, underlying anti-obesity mechanisms […]

Anticonvulsant Effects of N-Arachidonoyl-Serotonin, a Dual FAAH Enzyme and TRPV1 Channel Blocker, on Experimental Seizures: The Roles of Cannabinoid CB1 Receptors and TRPV1 Channels.

2014 Mar 27. doi: 10.1111/bcpt.12232. [Epub ahead of print] Anticonvulsant Effects of N-Arachidonoyl-Serotonin, a Dual FAAH Enzyme and TRPV1 Channel Blocker, on Experimental Seizures: The Roles of Cannabinoid CB1 Receptors and TRPV1 Channels. Vilela LR1, Medeiros DC, de Oliveira AC, Moraes MF, Moreira FA. Author information Abstract Selective blockade of anandamide hydrolysis, through inhibition of the FAAH enzyme, has anticonvulsant effects, […]

Rutin, a flavonoid and principal component of saussurea involucrata, attenuates physical fatigue in a forced swimming mouse model.

 2014 Mar 29;11(5):528-37. doi: 10.7150/ijms.8220. eCollection 2014. Rutin, a flavonoid and principal component of saussurea involucrata, attenuates physical fatigue in a forced swimming mouse model. Su KY1, Yu CY2, Chen YW2, Huang YT3, Chen CT2, Wu HF2, Chen YL2. Author information Abstract This study investigated the antifatigue effects of rutin, a flavonoid extracted from the ethyl acetate extract of S. involucrata. […]

Chemical approaches to therapeutically target the metabolism and signaling of the endocannabinoid 2-AG and eicosanoids.

 2014 Mar 28. [Epub ahead of print] Chemical approaches to therapeutically target the metabolism and signaling of the endocannabinoid 2-AG and eicosanoids. Kohnz RA1, Nomura DK. Author information Abstract The endocannabinoid system, most popularly known as the target of the psychoactive component of marijuana, Δ9-tetrahydrocannabinol (THC), is a signaling network that modulates a diverse range of […]

Federal red tape ties up marijuana research.

 2014 Mar 27;507(7493):407-8. doi: 10.1038/507407a. Federal red tape ties up marijuana research. Shen H. PMID:  24670737 [PubMed – indexed for MEDLINE] Publication Types, MeSH Terms, Substances Publication Types News MeSH Terms Biomedical Research/legislation & jurisprudence* Cannabidiol/analysis Cannabinol/analysis Cannabis/chemistry Cannabis/classification Cannabis/growth & development Child Colorado/epidemiology Data Collection/trends Dronabinol/analysis Federal Government* Female Humans Marijuana Smoking/economics Marijuana Smoking/epidemiology […]

Can Physical Exercise or Food Deprivation Cause Release of Fat-Stored Cannabinoids in Humans?

 2014 Mar 27. doi: 10.1111/bcpt.12235. [Epub ahead of print] Can Physical Exercise or Food Deprivation Cause Release of Fat-Stored Cannabinoids in Humans? Westin AA1, Mjønes G, Burchardt O, Fuskevåg OM, Slørdal L. Author information Abstract The aim of this study was to evaluate whether physical exercise or food deprivation may increase cannabionoid levels in serum or urine in abstinent chronic cannabis […]

The Potential of Antiseizure Drugs and Agents that Act on Novel Molecular Targets as Antiepileptogenic Treatments.

 2014 Mar 27. [Epub ahead of print] The Potential of Antiseizure Drugs and Agents that Act on Novel Molecular Targets as Antiepileptogenic Treatments. Kaminski RM1, Rogawski MA, Klitgaard H. Author information Abstract A major goal of contemporary epilepsy research is the identification of therapies to prevent the development of recurrent seizures in individuals at risk, including those […]

Role of anorectic N-acylethanolamines in intestinal physiology and satiety control with respect to dietary fat.

2014 Mar 27. pii: S1043-6618(14)00029-2. doi: 10.1016/j.phrs.2014.03.006. [Epub ahead of print] Role of anorectic N-acylethanolamines in intestinal physiology and satiety control with respect to dietary fat. Hansen HS. Author information Department of Drug Design and Pharmacology Faculty of Health and Medical Sciences, University of Copenhagen Universitetsparken 2 2100 Copenhagen, Denmark. Electronic address: hsh@sund.ku.dk. Abstract Anandamide […]

Delta-9-Tetrahydrocannabinol/Cannabidiol (Sativex®): A Review of Its Use in Patients with Moderate to Severe Spasticity Due to Multiple Sclerosis.

2014 Mar 27. [Epub ahead of print] Delta-9-Tetrahydrocannabinol/Cannabidiol (Sativex®): A Review of Its Use in Patients with Moderate to Severe Spasticity Due to Multiple Sclerosis. Syed YY1, McKeage K, Scott LJ. Author information Abstract Delta-9-tetrahydrocannabinol (THC)/cannabidiol (CBD) [Sativex®] is an oromucosal spray formulation that contains principally THC and CBD at an approximately 1:1 fixed ratio, derived from […]