Archive | September, 2014

The Role of Cytokine Responses During Influenza Virus Pathogenesis and Potential Therapeutic Options.

 2014 Sep 30. [Epub ahead of print] The Role of Cytokine Responses During Influenza Virus Pathogenesis and Potential Therapeutic Options. Teijaro JR. Author information  Abstract Aberrant pulmonary immune responses are linked to the pathogenesis of multiple human respiratory viral infections. Elevated cytokine and chemokine production “cytokine storm” has been continuously associated with poor clinical outcome and pathogenesis during influenza virus […]

A multicentre, open-label, follow-on study to assess the long-term maintenance of effect, tolerance and safety of THC/CBD oromucosal spray in the management of neuropathic pain.

2014 Sep 30. [Epub ahead of print] A multicentre, open-label, follow-on study to assess the long-term maintenance of effect, tolerance and safety of THC/CBD oromucosal spray in the management of neuropathic pain. Hoggart B1, Ratcliffe S, Ehler E, Simpson KH, Hovorka J, Lejčko J, Taylor L, Lauder H, Serpell M. Author information  Abstract Peripheral neuropathic pain (PNP) poses a significant clinical challenge. The […]

Cannabinoid receptor gene polymorphisms and bone mineral density in Korean postmenopausal women.

 2014 Sep 29. [Epub ahead of print] Cannabinoid receptor gene polymorphisms and bone mineral density in Korean postmenopausal women. Woo JH1, Kim H, Kim JH, Kim JG. Author information  Abstract OBJECTIVE: We investigated the association between single nucleotide polymorphisms in cannabinoid receptor (CNR) genes and bone mineral density (BMD) in Korean postmenopausal women. METHODS: Seven polymorphisms (rs2023239, rs806379, […]

Endocannabinoids Control Platelet Activation and Limit Aggregate Formation under Flow

PLoS One. 2014; 9(9): e108282.  Published online Sep 29, 2014. doi:  10.1371/journal.pone.0108282 PMCID: PMC4180465 Endocannabinoids Control Platelet Activation and Limit Aggregate Formation under Flow Valentina De Angelis, Arnold C. Koekman, Cees Weeterings, Mark Roest,Philip G. de Groot, Eszter Herczenik, and  Coen Maas* Kathleen Freson, Editor Author information ► Article notes ► Copyright and License information ► Go to: Abstract Background The endocannabinoid system has previously been implicated in the regulation […]

Protected: Who’s Protecting The *Children & *Their Families From Child And Family Services?

The purpose of the Child and Family Services Act is to protect children from harm, promote the integrity of the family and assure the best interests of children. In all proceedings and matters pursuant to this Act, the paramount consideration is the best interests of the child. If this is the case then who is […]

Cannabinoid receptor 2 deficiency results in reduced neuroinflammation in an Alzheimer’s disease mouse model.

 2014 Sep 28. pii: S0197-4580(14)00624-1. doi: 10.1016/j.neurobiolaging.2014.09.019. [Epub ahead of print] Cannabinoid receptor 2 deficiency results in reduced neuroinflammation in an Alzheimer’s disease mouse model. Schmöle AC1, Lundt R2, Ternes S2, Albayram O2, Ulas T3, Schultze JL3, Bano D4, Nicotera P4, Alferink J5, Zimmer A6. Author information  Abstract Several studies have indicated that the cannabinoid receptor 2 (CB2) plays an important role in neuroinflammation associated with Alzheimer’s […]

Mechanisms of Exercise-Induced Hypoalgesia.

Sep 23. pii: S1526-5900(14)00915-8. doi: 10.1016/j.jpain.2014.09.006. [Epub ahead of print] Mechanisms of Exercise-Induced Hypoalgesia. Koltyn KF1, Brellenthin AG2, Cook DB2, Sehgal N3, Hillard C4. Author information  Abstract The purpose of this study was to examine opioid and endocannabinoid mechanisms of exercise-induced hypoalgesia (EIH). Fifty-eight men and women (mean age = 21 yrs) completed three sessions. During the first session, […]

The interplay between inflammatory cytokines and the endocannabinoid system in the regulation of synaptic transmission.

 2014 Sep 28. pii: S0028-3908(14)00329-3. doi: 10.1016/j.neuropharm.2014.09.022. [Epub ahead of print] The interplay between inflammatory cytokines and the endocannabinoid system in the regulation of synaptic transmission. Rossi S1, Motta C1, Musella A1, Centonze D2. Author information  Abstract Excessive glutamate-mediated synaptic transmission and secondary excitotoxicity have been proposed as key determinants of neurodegeneration in many neurological diseases. Soluble mediators […]

Modulation of plasma N-acylethanolamine levels and physiological parameters by dietary fatty acid composition in humans.

2014 Sep 28. Modulation of plasma N-acylethanolamine levels and physiological parameters by dietary fatty acid composition in humans. Jones PJ1, Lin L2, Gillingham LG2, Yang H2, Omar JM2. Author information  JLR 2014-051235R Modulation of plasma N-acylethanolamine levels and physiological parameters by dietary fatty acid composition in humans Peter J.H. Jones1*, Lin Lin1, Leah G. Gillingham1, Haifeng Yang1, Jaclyn M. […]

Cannabinoid Receptor CB1 Is Involved in Nicotine-Induced Protection Against Aβ1-42 Neurotoxicity in HT22 Cells.

 2014 Sep 28. [Epub ahead of print] Cannabinoid Receptor CB1 Is Involved in Nicotine-Induced Protection Against Aβ1-42 Neurotoxicity in HT22 Cells. Wu M1, Jia J, Lei C, Ji L, Chen X, Sang H, Xiong L. Author information  Abstract Emerging evidences suggest that nicotine exerts a neuroprotective effect on Alzheimer’s disease (AD), yet the precise mechanism is not fully elucidated. Here, HT22 […]