Archive | April, 2015

Prescribing medical cannabis in Canada: Are we being too cautious?

 2015 Apr 30;106(5):e328-30. doi: 10.17269/cjph.106.4926. Lake S, Kerr T, Montaner J1. Author information Abstract There has been much recent discussion and debate surrounding cannabis in Canada, including the prescribing of medical cannabis for therapeutic purposes. Certain commentators – including the Canadian Medical Association (CMA) – have denounced the prescribing of cannabis for medical purposes due to a perceived lack of evidence related to […]

Cannabinoid Receptor-2 Regulates Embryonic Hematopoietic Stem Cell Development via PGE2 and P-selectin Activity.

2015 Apr 30. doi: 10.1002/stem.2044. [Epub ahead of print] Esain V1, Kwan W, Carroll KJ, Cortes M, Liu SY, Frechette GM, Sheward LM, Nissim S, Goessling W, North TE. Author information Abstract Cannabinoid Receptor-2  modulate adult hematopoietic stem and progenitor cell (HSPCs) function, however, impact on the production, expansion or migration of embryonic HSCs is currently uncharacterized. Here, using chemical and genetic approaches targeting CB-signaling […]

Endocannabinoid system activation may be associated with insulin resistance in women with polycystic ovary syndrome.

2015 Apr 29. pii: S0015-0282(15)00232-0. doi: 10.1016/j.fertnstert.2015.03.027. [Epub ahead of print] Juan CC1, Chen KH2, Wang PH3, Hwang JL4, Seow KM5. Author information Abstract OBJECTIVE: To assess the levels of endocannabinoids and cannabinoid receptors (CB) 1 and 2 in women with polycystic ovary syndrome (PCOS). DESIGN: Case-control study. SETTING: University teaching hospital. PATIENT(S): In total, 20 women with PCOS and 20 […]

Role of CB2 receptors in social and aggressive behavior in male mice.

 2015 Apr 29. [Epub ahead of print] Rodríguez-Arias M1, Navarrete F, Blanco-Gandia MC, Arenas MC, Aguilar MA, Bartoll-Andrés A, Valverde O, Miñarro J, Manzanares J. Author information Abstract RATIONALE: Male CB1KO mice exhibit stronger aggressive responses than wild-type mice. OBJECTIVE: This study was designed to examine the role of cannabinoid CB2r in social and aggressive behavior. METHODS: The social interaction test and resident-intruder paradigm were […]

The type 2 cannabinoid receptor regulates susceptibility to osteoarthritis in mice.

2015 Apr 29. pii: S1063-4584(15)01140-1. doi: 10.1016/j.joca.2015.04.020. [Epub ahead of print] Sophocleous A1, Börjesson AE2, Salter DM3, Ralston SH4. Author information Abstract OBJECTIVE: Cannabinoid receptors and their ligands have been implicated in the regulation of various physiological processes but their role in osteoarthritis has not been investigated. The aim of this study was to evaluate the role of the […]

A safer alternative: Cannabis substitution as harm reduction.

2015 Apr 28. doi: 10.1111/dar.12275. [Epub ahead of print] Lau N1, Sales P, Averill S, Murphy F, Sato SO, Murphy S. Author information Abstract INTRODUCTION AND AIMS: Substitution is operationalised as a conscious choice made by users to use one drug instead of, or in conjunction with another based on: perceived safety, level of addiction potential, effectiveness in relieving symptoms, […]

Enhancement of endocannabinoid signalling protects against cocaine-induced neurotoxicity.

2015 Apr 28. pii: S0041-008X(15)00155-6. doi: 10.1016/j.taap.2015.04.013. [Epub ahead of print] Vilela LR1, Gobira PH2, Viana TG2, Medeiros DC3, Ferreira-Vieira TH3, Doria JG1, Rodrigues F4, Aguiar DC2, Pereira GS3, Massessini AR3, Ribeiro FM4, de Oliveira AC2, Moraes MF5, Moreira FA6. Author information Abstract Cocaine is an addictive substance with a potential to cause deleterious effects in the brain. The strategies for treating its neurotoxicity, however, are limited. Evidence […]

Developing the Therapeutic Potential of the Endocannabinoid System for Pain Treatment (R01)

R01 Research Project Grant Announcement Type New Related Notices NOT-OD-16-004 – NIH & AHRQ Announce Upcoming Changes to Policies, Instructions and Forms for 2016 Grant Applications (November 18, 2015) NOT-OD-16-006 – Simplification of the Vertebrate Animals Section of NIH Grant Applications and Contract Proposals (November 18, 2015) NOT-OD-16-011 – Implementing Rigor and Transparency in NIH & AHRQ Research Grant […]

Accuracy of Self-reported Prescribed Analgesic Medication Use: Linkage between the Quebec Pain Registry and the Quebec Administrative Prescription Claims Databases.

 2015 Apr 28. [Epub ahead of print] Lacasse A1, Ware MA, Bourgault P, Lanctôt H, Dorais M, Boulanger A, Cloutier C, Shir Y, Choinière M. Author information Abstract OBJECTIVES: The validity of studies conducted with patient registries depends on the accuracy of the self-reported clinical data. As of now, studies about the validity of self-reported use of analgesics among chronic pain populations are […]

The Antitumor Activity of Plant-Derived Non-Psychoactive Cannabinoids.

2015 Apr 28. [Epub ahead of print] McAllister SD1, Soroceanu L, Desprez PY. Author information Abstract As a therapeutic agent, most people are familiar with the palliative effects of the primary psychoactive constituent of Cannabis sativa (CS), Δ9-tetrahydrocannabinol (THC), a molecule active at both the cannabinoid 1 (CB1) and cannabinoid 2 (CB2) receptor subtypes. Through the activation […]