Archive | April, 2017

Host-probiotic interaction: new insight into the role of the endocannabinoid system by in vivo and ex vivo approaches.

Sci Rep. 2017 Apr 28;7(1):1261. doi: 10.1038/s41598-017-01322-1. Gioacchini G1, Rossi G2, Carnevali O3,4. Author information Abstract The endocannabinoid system plays an important role in regulating inflammation in several chronic or anomalous gut inflammatory diseases. In vivo and ex vivo studies showed that 30 days treatment with a probiotic mix activated the endocannabinoid system in zebrafish. […]

Early Impacts of Marijuana Legalization: An Evaluation of Prices in Colorado and Washington.

J Prim Prev. 2017 Apr 29. doi: 10.1007/s10935-017-0471-x. [Epub ahead of print] Hunt P1,2, Pacula RL3,4. Author information Abstract Following the legalization and regulation of marijuana for recreational purposes in states with medical markets, policymakers and researchers seek empirical evidence on how, and how fast, supply and demand changed over time. Prices are an indication […]

Does Cannabis Composition Matter? Differential Effects of Delta-9-tetrahydrocannabinol and Cannabidiol on Human Cognition.

Curr Addict Rep. 2017;4(2):62-74. doi: 10.1007/s40429-017-0142-2. Epub 2017 Apr 29. Colizzi M1, Bhattacharyya S1. Author information Abstract PURPOSE OF REVIEW: The lack of clarity about the effect of cannabis use on cognition may be attributable to the considerable heterogeneity among studies in terms of cannabis composition. This article selectively reviews studies examining the distinctive effects […]

Neurosteroid biosynthesis downregulation and changes in GABAA receptor subunit composition: A biomarker axis in stress-induced cognitive and emotional impairment.

Br J Pharmacol. 2017 Apr 29. doi: 10.1111/bph.13843. [Epub ahead of print] Locci A1, Pinna G1. Author information 1 The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 W. Taylor Str., Chicago, IL, 60612, USA. Abstract By rapidly modulating neuronal excitability, neurosteroids regulate physiological processes, such as responses to stress and development. […]

Anti-neuroinflammatory effects of grossamide from hemp seed via suppression of TLR-4-mediated NF-κB signaling pathways in lipopolysaccharide-stimulated BV2 microglia cells.

Mol Cell Biochem. 2017 Apr;428(1-2):129-137. doi: 10.1007/s11010-016-2923-7. Epub 2017 Feb 21. Luo Q1, Yan X1, Bobrovskaya L2, Ji M1, Yuan H3, Lou H1, Fan P4. Author information Abstract Grossamide, a representative lignanamide in hemp seed, has been reported to possess potential anti-inflammatory effects. However, the potential anti-neuroinflammatory effects and underlying mechanisms of action of grossamide […]

Evidence for CB2 receptor involvement in LPS-induced reduction of cAMP intracellular levels in uterine explants from pregnant mice: pathophysiological implications.

Mol Hum Reprod. 2017 Apr 28. doi: 10.1093/molehr/gax026. [Epub ahead of print] Salazar AI1, Carozzo A2, Correa F1, Davio C2, Franchi AM1. Author information Abstract STUDY QUESTION: What is the role of the endocannabinoid system (eCS) on the lipopolysaccharide (LPS) effects on uterine explants from 7-day pregnant mice in a murine model of endotoxin-induced miscarriage? […]

Evaluating the Change in Medical Marijuana Dispensary Locations in Los Angeles Following the Passage of Local Legislation.

J Prim Prev. 2017 Apr 28. doi: 10.1007/s10935-017-0473-8. [Epub ahead of print] Thomas C1, Freisthler B2. Author information Abstract In May 2013, Los Angeles voters approved Proposition D, a regulatory measure that set zoning restrictions and capped the number of dispensaries at those that opened before 2007. Specifically, Proposition D stated that only 135 dispensaries […]

Formulation, Characterization and Properties of Hemp Seed Oil and Its Emulsions.

Molecules. 2017 Apr 27;22(5). pii: E700. doi: 10.3390/molecules22050700. Mikulcová V1, Kašpárková V2,3, Humpolíček P4,5, Buňková L6. Author information Abstract The formulation, characterization, and anticipated antibacterial properties of hemp seed oil and its emulsions were investigated. The oil obtained from the seeds of Cannabis sativa L. in refined and unrefined form was characterized using iodine, saponification, acid […]

GPR55 and the regulation of glucose homeostasis.

Int J Biochem Cell Biol. 2017 Apr 27. pii: S1357-2725(17)30088-2. doi: 10.1016/j.biocel.2017.04.010. [Epub ahead of print] Tudurí E1, López M2, Diéguez C2, Nadal A3, Nogueiras R4. Author information Abstract Pathophysiological conditions such as obesity and type 2 diabetes (T2D) are reportedly associated to over-activation of the endocannabinoid system (ECS). Therefore, modulation of the ECS offers […]

The psychoneuroendocrine-immunotherapy of cancer: Historical evolution and clinical results.

J Res Med Sci. 2017 Apr 26;22:45. doi: 10.4103/jrms.JRMS_255_16. eCollection 2017. Lissoni P1, Messina G1, Lissoni A1, Franco R1. Author information Abstract The prognosis of the neoplastic diseases depends not only on the biogenetic characteristics of cancer cells but also on the immunological response of patients, which may influence the biological features of cancer cells […]