Canna~Fangled Abstracts

GPR55 and the regulation of glucose homeostasis.

By April 27, 2017 No Comments
Int J Biochem Cell Biol. 2017 Apr 27. pii: S1357-2725(17)30088-2. doi: 10.1016/j.biocel.2017.04.010.
[Epub ahead of print]


pm-2-site-207Pathophysiological conditions such as obesity and type 2 diabetes (T2D) are reportedly associated to over-activation of the endocannabinoid system (ECS). Therefore, modulation of the ECS offers potential therapeutic benefits on those diseases. GPR55, the receptor for L-α-lysophosphatidylinositol (LPI) that has also affinity for various cannabinoid ligands, is distributed at the central and peripheral level and it is involved in several physiological processes. This review summarizes the localization and role of GPR55 in tissues that are crucial for the regulation of glucose metabolism, and provides an update on its contribution in obesity and insulin resistance. The therapeutic potential of targeting the GPR55 receptor is also discussed.


endocannabinoids; insulin; islets; obesity

PMID: 28457969


DOI: 10.1016/j.biocel.2017.04.010
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