Canna~Fangled Abstracts

2012 division of medicinal chemistry award address. Trekking the cannabinoid road: a personal perspective.

By May 22, 2014No Comments
2014 May 22;57(10):3891-911. doi: 10.1021/jm500220s. Epub 2014 May 1.

pm82012 division of medicinal chemistry award address. Trekking the cannabinoid road: a personal perspective.

Abstract

My involvement with the field of cannabinoids spans close to 3 decades and covers a major part of my scientific career. It also reflects the robust progress in this initially largely unexplored area of biology. During this period of time, I have witnessed the growth of modern cannabinoid biology, starting from the discovery of its two receptors and followed by the characterization of its endogenous ligands and the identification of the enzyme systems involved in their biosynthesis and biotransformation. I was fortunate enough to start at the beginning of this new era and participate in a number of the new discoveries. It has been a very exciting journey. With coverage of some key aspects of my work during this period of “modern cannabinoid research,” this Award Address, in part historical, intends to give an account of how the field grew, the key discoveries, and the most promising directions for the future.
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24707904

 

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Center for Drug Discovery and Departments of Chemistry and Chemical Biology and Pharmaceutical Sciences, Northeastern University, 360 Huntington Avenue, Boston, Massachusetts 02115, United States
J. Med. Chem., 2014, 57 (10), pp 3891–3911
DOI: 10.1021/jm500220s
Publication Date (Web): April 7, 2014
Copyright © 2014 American Chemical Society
*Phone: +16173734200. E-mail: a.makriyannis@neu.edu.
BiographyAlexandros Makriyannis is the George Behrakis Trustee Chair in Pharmaceutical Biotechnology; Professor of Pharmaceutical Sciences, Chemistry, and Chemical Biology; and Director of the Center for Drug Discovery at Northeastern University, MA. He received his Ph.D. in Medicinal Chemistry at the University of Kansas and postdoctoral training in synthetic organic chemistry at the University of California, Berkeley. At the University of Connecticut, he rose to the rank of Distinguished Professor before joining Northeastern University and establishing its Center for Drug Discovery. His work is characterized by being at the interface of chemistry and biology, encompassing over 450 publications, 40 patents, and numerous awards, most recently the Northeastern Award for Excellence in Research and Creativity (2012) and the ACS Medicinal Chemistry Hall of Fame (2013).
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Abstract

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My involvement with the field of cannabinoids spans close to 3 decades and covers a major part of my scientific career. It also reflects the robust progress in this initially largely unexplored area of biology. During this period of time, I have witnessed the growth of modern cannabinoid biology, starting from the discovery of its two receptors and followed by the characterization of its endogenous ligands and the identification of the enzyme systems involved in their biosynthesis and biotransformation. I was fortunate enough to start at the beginning of this new era and participate in a number of the new discoveries. It has been a very exciting journey. With coverage of some key aspects of my work during this period of “modern cannabinoid research,” this Award Address, in part historical, intends to give an account of how the field grew, the key discoveries, and the most promising directions for the future.

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