Archive | August, 2017

Proximal Tubular Cannabinoid-1 Receptor Regulates Obesity-Induced CKD.

J Am Soc Nephrol. 2017 Aug 31. pii: ASN.2016101085. doi: 10.1681/ASN.2016101085. [Epub ahead of print] Udi S1, Hinden L1, Earley B2, Drori A1, Reuveni N1, Hadar R1, Cinar R2, Nemirovski A1, Tam J3. Author information Abstract Obesity-related structural and functional changes in the kidney develop early in the course of obesity and occur independently of […]

Mechanisms of action of cannabidiol in adoptively transferred experimental autoimmune encephalomyelitis.

Exp Neurol. 2017 Aug 31. pii: S0014-4886(17)30221-2. doi: 10.1016/j.expneurol.2017.08.017. [Epub ahead of print] González-García C1, Torres IM2, García-Hernández R3, Campos-Ruíz L4, Esparragoza LR5, Coronado MJ6, Grande AG7, García-Merino A8, Sánchez López AJ9. Author information Abstract Cannabidiol (CBD) is one of the most important compounds in Cannabis sativa, lacks psychotropic effects, and possesses a high number […]

Effects of arachidonyl-2′-chloroethylamide (ACEA) on the protective action of various antiepileptic drugs in the 6-Hz corneal stimulation model in mice.

PLoS One. 2017 Aug 31;12(8):e0183873. doi: 10.1371/journal.pone.0183873. eCollection 2017. Luszczki JJ1,2, Patrzylas P2,3, Zagaja M2, Andres-Mach M2, Zaluska K1, Kondrat-Wrobel MW1, Szpringer M4, Chmielewski J5, Florek-Luszczki M6. Author information Abstract Accumulating evidence indicates that cannabinoid CB1 receptor ligands play a pivotal role in seizures, not only in preclinical studies on animals, but also in clinical […]

Modulating the endocannabinoid pathway as treatment for peripheral neuropathic pain: a selected review of preclinical studies.

Ann Palliat Med. 2017 Aug 31. pii: apm.2017.08.04. doi: 10.21037/apm.2017.08.04. [Epub ahead of print] O’Hearn S1, Diaz P2, Wan BA2, DeAngelis C2, Lao N3, Malek L2, Chow E2, Blake A3. Author information Abstract Chemotherapy-induced neuropathic pain is a distressing and commonly occurring side effect of many commonly used chemotherapeutic agents, which in some cases may […]

Developmental programming of somatic growth, behavior and endocannabinoid metabolism by variation of early postnatal nutrition in a cross-fostering mouse model.

Felix Schreiner, Merle Ackermann, Michael Michalik, Eva Hucklenbruch-Rother, Andras Bilkei-Gorzo, Ildiko Racz, Laura Bindila, Beat Lutz, Jörg Dötsch, Andreas Zimmer, Joachim Woelfle Published: August 31, 2017 Article Authors Metrics Comments Related Content Abstract Introduction Material and methods Results Discussion Supporting information References Reader Comments (0) Media Coverage (0) Figures Abstract Background Nutrient deprivation during early development has been associated with the predisposition to metabolic […]

The Endogenous Cannabinoid System: A Budding Source of Targets for Treating Inflammatory and Neuropathic Pain.

Neuropsychopharmacology. 2017 Aug 31. doi: 10.1038/npp.2017.204. [Epub ahead of print] Donvito G1, Nass SR2, Wilkerson JL1, Curry ZA1, Schurman LD1, Kinsey SG2, Lichtman AH1. Author information Abstract A great need exists for the development of new medications to treat pain resulting from various disease states and types of injury. Given that the endogenous cannabinoid (ie, […]

Endocannabinoid Interaction with Human FABP1: Impact of T94A Variant.

Biochemistry. 2017 Aug 30. doi: 10.1021/acs.biochem.7b00647. [Epub ahead of print] Martin GG, Huang H, McIntosh AL, Kier AB, Schroeder F. Abstract Using recombinant human wild-type fatty acid binding protein 1 (WT FABP1 T94T) and variant (FABP1 T94A) protein, fluorescence binding assays, and circular dichroism, it was shown for the first time that WT FABP1 and […]

Fatty acid amide hydrolase (FAAH) inhibitor PF-3845 reduces viability, migration and invasiveness of human colon adenocarcinoma Colo-205 cell line: an in vitro study.

Acta Biochim Pol. 2017 Aug 30. doi: 10.18388/abp.2017_1520. [Epub ahead of print] Wasilewski A1, Krajewska U2, Owczarek K1, Lewandowska U1, Fichna J1. Author information Abstract Earlier reports suggest that the endocannabinoids may play a role of endogenous tumor growth modulators. In this study, we investigated whether inhibition of the enzymes involved in the synthesis and […]

Tetrahydrocannabinolic acid is a potent PPARγ agonist with neuroprotective activity.

Br J Pharmacol. 2017 Aug 29. doi: 10.1111/bph.14019. [Epub ahead of print] Nadal X1, Del Río C2, Casano S1, Palomares B2, Ferreiro-Vera C1, Navarrete C3, Sánchez-Carnerero C1, Cantarero I2, Luz Bellido M3, Meyer S1, Morello G4, Appendino G5, Muñoz E2. Author information Abstract BACKGROUND AND PURPOSE: Phytocannabinoids are produced in Cannabis sativa L. in acidic […]

Therapeutical strategies for anxiety and anxiety-like disorders using plant-derived natural compounds and plant extracts.

Biomed Pharmacother. 2017 Aug 29;95:437-446. doi: 10.1016/j.biopha.2017.08.107. [Epub ahead of print] Fedotova J1, Kubatka P2, Büsselberg D3, Shleikin AG4, Caprnda M5, Dragasek J6, Rodrigo L7, Pohanka M8, Gasparova I9, Nosal V10, Opatrilova R11, Qaradakhi T12, Zulli A12, Kruzliak P13. Author information Abstract Anxiety and anxiety-like disorders describe many mental disorders, yet fear is a common […]