Archive | September, 2017

White-rot fungi pretreatment combined with alkaline/oxidative pretreatment to improve enzymatic saccharification of industrial hemp.

Bioresour Technol. 2017 Nov;243:188-195. doi: 10.1016/j.biortech.2017.06.077. Epub 2017 Jun 17. Xie C1, Gong W1, Yang Q1, Zhu Z1, Yan L1, Hu Z1, Peng Y2. Author information Abstract White-rot fungi combined with alkaline/oxidative (A/O) pretreatments of industrial hemp woody core were proposed to improve enzymatic saccharification. In this study, hemp woody core were treated with only […]

Nongenomic Glucocorticoid Suppression of a Postsynaptic Potassium Current via Emergent Autocrine Endocannabinoid Signaling in Hypothalamic Neuroendocrine Cells following Chronic Dehydration.

eNeuro. 2017 Sep 19;4(5). pii: ENEURO.0216-17.2017. doi: 10.1523/ENEURO.0216-17.2017. eCollection 2017 Sep-Oct. Wu N1, Tasker JG1,2. Author information Abstract Glucocorticoids rapidly stimulate endocannabinoid synthesis and modulation of synaptic transmission in hypothalamic neuroendocrine cells via a nongenomic signaling mechanism. The endocannabinoid actions are synapse-constrained by astrocyte restriction of extracellular spatial domains. Exogenous cannabinoids have been shown to […]

An Exploratory Study of Cannabis Festivals and Their Attendees in Two European Cities: Amsterdam and Berlin.

J Psychoactive Drugs. 2017 Sep 29:1-9. doi: 10.1080/02791072.2017.1380869. [Epub ahead of print] Skliamis K1, Korf DJ2. Author information Abstract This study was designed to explore the nature and features of cannabis festivals, characteristics of festival participants, and reasons for attendance. A field study in two European cities (Amsterdam and Berlin) included participant observation at the […]

A Resurging Boom in New Drugs for Epilepsy and Brain Disorders.

Expert Rev Clin Pharmacol. 2017 Sep 28. doi: 10.1080/17512433.2018.1386553. [Epub ahead of print] Younus I1, Reddy DS2. Author information Abstract INTRODUCTION: Epilepsy is one of the most common neurological diseases affecting approximately 50 million people worldwide. Despite many advances in epilepsy research, nearly a third of patients with epilepsy have refractory or pharmacoresistant epilepsy. Despite […]

Retromer stops beta-arrestin 1 mediated signaling from internalized cannabinoid 2 receptors.

Mol Biol Cell. 2017 Sep 27. pii: mbc.E17-03-0198. doi: 10.1091/mbc.E17-03-0198. [Epub ahead of print] Nogueras-Ortiz C1, Roman-Vendrell C1,2, Mateo-Semidey GE1,3, Liao YH4, Kendall DA4, Yudowski GA5,3. Author information Abstract G protein-coupled receptors (GPCRs) mediate their complex functions through activation of signaling cascades from receptors localized at the cell surface and endosomal compartments. These signaling pathways […]

Cannabidiol and Palmitoylethanolamide are anti-inflammatory in the acutely inflamed human colon.

Clin Sci (Lond). 2017 Sep 27. pii: CS20171288. doi: 10.1042/CS20171288. [Epub ahead of print] Couch DG1, Tasker C2, Theophilidou E2, Lund JN3, O’Sullivan SE2. Author information Abstract Objective: We sought to quantify the anti-inflammatory effects of two cannabinoid drugs: cannabidiol (CBD) and palmitoylethanolamide (PEA), in cultured cell lines and compared this effect with experimentally inflamed […]

Development of terphenyl-2-methyloxazol-5(4H)-one derivatives as selective reversible MAGL inhibitors.

J Enzyme Inhib Med Chem. 2017 Dec;32(1):1240-1252. doi: 10.1080/14756366.2017.1375484. Granchi C1, Caligiuri I2, Bertelli E1, Poli G1, Rizzolio F3, Macchia M1, Martinelli A1, Minutolo F1, Tuccinardi T1,4. Author information Abstract Monoacylglycerol lipase is a serine hydrolase that plays a major role in the degradation of the endocannabinoid neurotransmitter 2-arachidonoylglycerol. A wide number of MAGL inhibitors […]

Synergistic interaction of the cannabinoid and death receptor systems: A potential target for future cancer therapies?

FEBS Lett. 2017 Sep 26. doi: 10.1002/1873-3468.12863. [Epub ahead of print] Keresztes A1, Streicher JM1. Author information Abstract Cannabinoid receptors have been shown to interact with other receptors, including Tumor Necrosis Factor Receptor Superfamily (TNFRS) members, to induce cancer cell death. When cannabinoids and death-inducing ligands (including TRAIL) are administered together, they have been shown […]

Textile Hemp vs. Salinity: Insights from a Targeted Gene Expression Analysis

Genes (Basel). 2017 Sep 26;8(10). pii: E242. doi: 10.3390/genes8100242. Guerriero G1, Behr M2, Hausman JF3, Legay S4. Author information Abstract Soil salinity is a serious threat to agriculture, because it compromises biomass production and plant productivity, by negatively affecting the vegetative growth and development of plants. Fiber crops like textile hemp (Cannabis sativa L.) are […]

Preferences for Medical Marijuana over Prescription Medications Among Persons Living with Chronic Conditions: Alternative, Complementary, and Tapering Uses.

J Altern Complement Med. 2017 Sep 25. doi: 10.1089/acm.2017.0184. [Epub ahead of print] Bruce D1, Brady JP2, Foster E3, Shattell M4. Author information Abstract OBJECTIVES: Despite expanded legalization and utilization of medical cannabis (MC) internationally, there is a lack of patient-centered data on how MC is used by persons living with chronic conditions in tandem […]