Canna~Fangled Abstracts

Synergistic interaction of the cannabinoid and death receptor systems: A potential target for future cancer therapies?

By September 26, 2017 No Comments
FEBS Lett. 2017 Sep 26. doi: 10.1002/1873-3468.12863.
[Epub ahead of print]


PM 2 site 207Cannabinoid receptors have been shown to interact with other receptors, including Tumor Necrosis Factor Receptor Superfamily (TNFRS) members, to induce cancer cell death. When cannabinoids and death-inducing ligands (including TRAIL) are administered together, they have been shown to synergize and demonstrate enhanced antitumor activity in vitro. Certain cannabinoid ligands have been shown to sensitize cancer cells and synergistically interact with members of the TNFRS, thus suggesting that the combination of cannabinoids with death receptor (DR) ligands induces additive or synergistic tumor cell death. This review summarizes recent findings on the interaction of the cannabinoid and DR systems and suggests possible clinical co-application of cannabinoids and DR ligands in the treatment of various malignancies. This article is protected by copyright. All rights reserved.


Apoptosis; Cancer; Cannabinoid; TNF-related apoptosis-inducing ligand (TRAIL); combination therapy; death receptor (DR)

PMID: 28948607
DOI: 10.1002/1873-3468.12863

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Publication type

twin memes II

en English