Thermal isomerization of cannabinoid analogues.
Source
Department of Chemistry, University of California, Riverside, California 92521, USA.
Abstract
Thermal isomerization of CBC(an) to THC(an) [nonaromatic analogues of plant cannabinoidscannabichromene (CBC) and Delta(1)-tetrahydrocannabinol (THC), respectively] is predicted in silico and demonstrated experimentally. Density functional theory calculations support a similar isomerization mechanism for the corresponding plant cannabinoids. Docking studies suggest that THC(an), although nonaromatic, has a CB(1) receptor binding affinity similar to that of natural THC.
- PMID:
19919138
[PubMed – indexed for MEDLINE]
LinkOut – more resources
Thermal isomerization of CBCan to THCan [nonaromatic analogues of plant cannabinoids cannabichromene (CBC) and Δ1-tetrahydrocannabinol (THC), respectively] is predicted in silico and demonstrated experimentally. Density functional theory calculations support a similar isomerization mechanism for the corresponding plant cannabinoids. Docking studies suggest that THCan, although nonaromatic, has a CB1 receptor binding affinity similar to that of natural THC.
