Skip to main content
Canna~Fangled Abstracts

Endocannabinoid signaling pathways: beyond CB1R and CB2R

By May 13, 2021No Comments
Review

doi: 10.1007/s12079-021-00622-6.

Online ahead of print.
Affiliations 

Abstract

The search for cannabinoid receptors other than CB1R and CB2R has been ongoing for over a decade. A number of orphan receptors have been proposed as potential cannabinoid receptors primarily based on phylogenic arguments and reactivity towards known endocannabinoids and phytocannabinoids. Seven putative cannabinoid receptors are described and discussed, and evidence for and against their inclusion in this category are presented.

 

Keywords: 2-Acyl glycerol, Anandamide, Cannabinoid, Endocannabinoid, Phytocannabinoid

References

    1. Anavi-Goffer S, Baillie G, Irving AJ, Gertsch J, Greig IR, Pertwee RG, Ross RA (2012) Modulation of L-α-lysophosphatidylinositol/GPR55 mitogen-activated protein kinase (MAPK) signaling by cannabinoids. J Biol Chem 287(1):91–104. https://doi.org/10.1074/jbc.M111.296020 – DOI – PubMed
    1. Baggelaar MP, Maccarrone M, van der Stelt M (2018) 2-Arachidonoylglycerol: a signaling lipid with manifold actions in the brain. Prog Lipid Res 71:1–17. https://doi.org/10.1016/j.plipres.2018.05.002 – DOI – PubMed
    1. Balenga NA, Aflaki E, Kargl J, Platzer W, Schröder R, Blättermann S, Kostenis E, Brown AJ, Heinemann A, Waldhoer M (2011) GPR55 regulates cannabinoid 2 receptor-mediated responses in human neutrophils. Cell Res 21(10):1452–1469. https://doi.org/10.1038/cr.2011.60 – DOI – PubMed – PMC
    1. Becker AM, Callahan DJ, Richner JM, Choi J, DiPersio JF, Diamond MS, Bhattacharya D (2015) GPR18 controls reconstitution of mouse small intestine intraepithelial lymphocytes following bone marrow transplantation. PLoS ONE 10(7):e0133854. https://doi.org/10.1371/journal.pone.0133854 – DOI – PubMed – PMC
    1. Bédard A, Tremblay P, Chernomoretz A, Vallières L (2007) Identification of genes preferentially expressed by microglia and upregulated during cuprizone-induced inflammation. Glia 55(8):777–789. https://doi.org/10.1002/glia.20477 – DOI – PubMed

Publication types


Leave a Reply