COMMENTARY
Abbreviations
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- CBD
-
- cannabidiol
-
- CBGA
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- Cannabigerolic acid
-
- PAM
-
- positive allosteric modulator
Taken together, this study by Anderson et al. is an important contribution to our understanding of cannabinoid pharmacology and suggests several avenues of future research which will help increase our understanding of some of the major cannabinoids found in cold-extracted artisanal cannabis products. This study also highlights some of the potential pitfalls of current community use of artisanal cannabis products to treat epilepsy; the exact mix and concentration of cannabinoids present in these products could have profound effects on anti-seizure and proconvulsant potential of these products. However, this study clearly demonstrates that full investigation of the potential of phytocannabinoids including CBGA could still be a potential source of novel and lead compounds for the treatment of drug resistant forms of epilepsy.
NOMENCLATURE OF TARGETS AND LIGANDS
Key protein targets and ligands in this article are hyperlinked to corresponding entries in the IUPHAR/BPS Guide to PHARMACOLOGY http://www.guidetopharmacology.org and are permanently archived in the Concise Guide to PHARMACOLOGY 2021/22 (Alexander, Christopoulos et al., 2021; Alexander, Mathie et al., 2021).