Skip to main content
Canna~Fangled Abstracts

Assessment of clinical outcomes in patients with fibromyalgia: Analysis from the UK Medical Cannabis Registry

By May 18, 2023No Comments

. 2023 May 18;e3072.

doi: 10.1002/brb3.3072.

Online ahead of print.
Claire Wang 1, Simon Erridge 1 2, Carl Holvey 2, Ross Coomber 2 3, Azfer Usmani 2, Mohammed Sajad 2, Rahul Guru 2, Wendy Holden 2, James J Rucker 2 4 5, Michael W Platt 1 2, Mikael H Sodergren 1 2
Affiliations 

Abstract

Introduction: There are limited therapeutic options for individuals with fibromyalgia. The aim of this study is to analyze changes in health-related quality of life and incidence of adverse events of those prescribed cannabis-based medicinal products (CBMPs) for fibromyalgia.

Methods: Patients treated with CBMPs for a minimum of 1 month were identified from the UK Medical Cannabis Registry. Primary outcomes were changes in validated patient-reported outcome measures (PROMs). A p-value of <.050 was deemed statistically significant.

Results: In total, 306 patients with fibromyalgia were included for analysis. There were improvements in global health-related quality of life at 1, 3, 6, and 12 months (p < .0001). The most frequent adverse events were fatigue (n = 75; 24.51%), dry mouth (n = 69; 22.55%), concentration impairment (n = 66; 21.57%), and lethargy (n = 65; 21.24%).

Conclusion: CBMP treatment was associated with improvements in fibromyalgia-specific symptoms, in addition to sleep, anxiety, and health-related quality of life. Those who reported prior cannabis use appeared to have a greater response. CBMPs were generally well-tolerated. These results must be interpreted within the limitations of study design.

Keywords: cannabidiol, fibromyalgia, medical cannabis, tetrahydrocannabinol

References

REFERENCES

    1. Ablin, J. N., & Sarzi-Puttini, P. (2020). The Second International Congress on Controversies in Fibromyalgia; 12-13 March 2020, Berlin, Germany. Clinical and Experimental Rheumatology, 38(1), 105-130.
    1. Akirav, I. (2011). The role of cannabinoids in modulating emotional and non-emotional memory processes in the hippocampus. Frontiers in Behavioral Neuroscience, 5, 34. https://doi.org/10.3389/FNBEH.2011.00034
    1. Althubaiti, A. (2016). Information bias in health research: Definition, pitfalls, and adjustment methods. Journal of Multidisciplinary Healthcare, 9, 211-217. https://doi.org/10.2147/JMDH.S104807
    1. Andre, C. M., Hausman, J. F., & Guerriero, G. (2016). Cannabis sativa: The plant of the thousand and one molecules. Frontiers in Plant Science, 7, 19. https://doi.org/10.3389/FPLS.2016.00019/BIBTEX
    1. Anthony, A. T., Rahmat, S., Sangle, P., Sandhu, O., & Khan, S. (2020). Cannabinoid receptors and their relationship with chronic pain: A narrative review. Cureus, 12(9), e10436. https://doi.org/10.7759/cureus.10436

Leave a Reply