2014 Jun 11. doi: 10.1038/nrn3772. [Epub ahead of print]
Endocannabinoids: A protective receptor pool.
PMID: 24917301 [PubMed – as supplied by publisher]
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ENDOCANNABINOIDS
A protective receptor pool
- Nature Reviews Neuroscience
doi:10.1038/nrn3772
- Published online
Endocannabinoids have neuroprotective effects in animal models of neurodegenerative disorders, but the underlying mechanism has remained unclear. Guzmán and colleagues now show that the presence of CB1 cannabinoid receptors (CB1Rs) at the terminals of glutamatergic corticostriatal neurons prevents excitotoxicity in the striatum and thereby has neuroprotective effects in a mouse…
References
- Chiarlone, A. et al. A restricted population of CB1 cannabinoid receptors with neuroprotective activity. Proc. Natl Acad. Sci. USA http://dx.doi.org/10.1073/pnas.1400988111 (2014)
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