Tag Archives: endocannabinoids
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Endocannabinoid Metabolome Characterization of Transitional and Mature Human Milk.

Nutrients. 2018 Sep 12;10(9). pii: E1294. doi: 10.3390/nu10091294. Gaitán AV1, Wood JT2, Zhang F3, Makriyannis A4, Lammi-Keefe CJ5,6. Author information Abstract Recognized as the gold standard, human milk (HM) is an extremely complex yet fascinating biofluid tailored to meet an infant’s nutritional requirements throughout development. Endocannabinoids and endocannabinoid-like compounds (endocannabinoid metabolome, ECM) are endogenous lipid […]

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Cannabis sativa: A comprehensive ethnopharmacological review of a medicinal plant with a long history.

J Ethnopharmacol. 2018 Sep 8. pii: S0378-8741(18)31661-1. doi: 10.1016/j.jep.2018.09.004. [Epub ahead of print] Bonini SA1, Premoli M1, Tambaro S2, Kumar A3, Maccarinelli G1, Memo M1, Mastinu A4. Author information Abstract ETHNOPHARMACOLOGICAL RELEVANCE: Cannabis sativa L. (C. sativa) is an annual dioecious plant, which shares its origins with the inception of the first agricultural human societies […]

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Glucocorticoid interactions with the dorsal striatal endocannabinoid system in regulating inhibitory avoidance memory.

Psychoneuroendocrinology. 2018 Aug 30;99:97-103. doi: 10.1016/j.psyneuen.2018.08.021. [Epub ahead of print] Siller-Pérez C1, Fuentes-Ibañez A2, Sotelo-Barrera EL3, Serafín N4, Prado-Alcalá RA5, Campolongo P6, Roozendaal B7, Quirarte GL8. Author information Abstract The endocannabinoid (eCB) system is highly stress sensitive and known to modulate memory formation of emotionally arousing experiences across different corticolimbic structures. eCB signaling within these […]

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The Endocannabinoid/Cannabinoid Receptor 2 System Protects Against Cisplatin-Induced Hearing Loss.

Front Cell Neurosci. 2018 Aug 21;12:271. doi: 10.3389/fncel.2018.00271. eCollection 2018. Ghosh S1, Sheth S1, Sheehan K2, Mukherjea D2, Dhukhwa A1, Borse V3, Rybak LP1,2, Ramkumar V1. Author information Abstract Previous studies have demonstrated the presence of cannabinoid 2 receptor (CB2R) in the rat cochlea which was induced by cisplatin. In an organ of Corti-derived cell […]

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Cannabinoid receptor-1 signaling contributions to sign-tracking and conditioned reinforcement in rats.

Psychopharmacology (Berl). 2018 Aug 14. doi: 10.1007/s00213-018-4993-6. [Epub ahead of print] Bacharach SZ1,2, Nasser HM1, Zlebnik NE1, Dantrassy HM1, Kochli DE1, Gyawali U1,2, Cheer JF1,2,3, Calu DJ4,5. Author information Abstract RATIONALE: Endocannabinoids (eCBs) are critical gatekeepers of dopaminergic signaling, and disrupting cannabinoidreceptor-1 (CB1) signaling alters DA dynamics to attenuate cue-motivated behaviors. Prior studies suggest that […]

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Host and helminth-derived endocannabinoids are generated during infection with effects on host immunity.

Infect Immun. 2018 Aug 13. pii: IAI.00441-18. doi: 10.1128/IAI.00441-18. [Epub ahead of print] Batugedara HM1, Argueta D1, Jang JC1, Lu D2, Macchietto M3, Kaur J1, Ge S1, Dillman AR2, DiPatrizio NV4, Nair MG5. Author information Abstract Helminths have co-evolved with their hosts resulting in the development of specialized host immune mechanisms and parasite-specific regulatory products. […]

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Food for Mood: Relevance of Nutritional Omega-3 Fatty Acids for Depression and Anxiety.

Front Physiol. 2018 Aug 6;9:1047. doi: 10.3389/fphys.2018.01047. eCollection 2018. Larrieu T1, Layé S1. Author information Abstract The central nervous system (CNS) has the highest concentration of lipids in the organism after adipose tissue. Among these lipids, the brain is particularly enriched with polyunsaturated fatty acids (PUFAs) represented by the omega-6 (ω6) and omega-3 (ω3) series. […]

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Endocannabinoid Anandamide Mediates the Effect of Skeletal Muscle Sphingomyelins on Human Energy Expenditure.

J Clin Endocrinol Metab. 2018 Aug 2. doi: 10.1210/jc.2018-00780. [Epub ahead of print] Heinitz S1,2, Basolo A1, Piomelli D3, Krakoff J1, Piaggi P1. Author information Abstract CONTEXT: Skeletal muscle endocannabinoids and sphingolipids (particularly, sphingomyelins) are inversely associated with sleeping energy expenditure (SLEEP) in humans. The endocannabinoid system may increase sphingolipid synthesis via cannabinoid receptor-1. OBJECTIVE: […]

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Brain activity of anandamide: a rewarding bliss?

Acta Pharmacol Sin. 2018 Jul 26. doi: 10.1038/s41401-018-0075-x. [Epub ahead of print] Scherma M1, Masia P1, Satta V1, Fratta W1, Fadda P1,2,3, Tanda G4. Author information Abstract Anandamide is a lipid mediator that acts as an endogenous ligand of CB1 receptors. These receptors are also the primary molecular target responsible for the pharmacological effects of […]

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Therapeutic applications of cannabinoids.

Chem Biol Interact. 2018 Jul 21. pii: S0009-2797(18)30737-3. doi: 10.1016/j.cbi.2018.07.018. [Epub ahead of print] Velmurugan BK1. Author information Abstract The psychoactive properties of cannabinoids are well known and there has been a continuous controversy regarding the usage of these compounds for therapeutic purposes all over the world. Their use for medical and research purposes are […]