doi: 10.1038/s41429-024-00793-5.
- PMID: 39627321
- DOI: 10.1038/s41429-024-00793-5
Abstract
A new derivative of cannabigerolic acid, designated as iso-cannabigerolic acid (iso-CBGA), a member of the cannabinoid family, and its precursor iso-olivetolic acid (iso-OA) were discovered from the culture of the engineered Streptomyces avermitilis heterologously expressing the genes responsible for cannabigerolic acid biosynthesis. Structural determination revealed an iso-pentyl moiety, which may arise from the biosynthetic precursor pool present in S. avermitilis. We describe herein the culture, isolation, structure determination and antibacterial activities of iso-CBGA and iso-OA.
© 2024. The Author(s), under exclusive licence to the Japan Antibiotics Research Association.
Conflict of interest statement
Compliance with ethical standards. Conflict of interest: The authors declare no competing interests.
References
-
- Shah SA, Gupta AS, Kumar P. Emerging role of cannabinoids and synthetic cannabinoid receptor 1/cannabinoid receptor 2 receptor agonists in cancer treatment and chemotherapy-associated cancer management. J Cancer Res Ther. 2021;17:1–9. – DOI – PubMed
- Pacher P, Batkai S, Kunos G. The endocannabinoid system as an emerging target of pharmacotherapy. Pharm Rev. 2006;58:389–462. – DOI – PubMed
- Bonini SA, Premoli M, Tambaro S, Kumar A, Maccarinelli G, Memo M, et al. Cannabis sativa: A comprehensive ethnopharmacological review of a medicinal plant with a long history. J Ethnopharmacol. 2018;227:300–15. – DOI – PubMed
Grants and funding
