Sub-chronic administration of AM6545 enhances cognitive performance and induces hippocampal synaptic plasticity changes in naïve mice

• PMID: 40102206
• DOI: 10.1111/bph.70015

Introduction:
AM6545 cognitive enhancement shows promise in boosting cognitive function and improving hippocampal synaptic plasticity in mice. This study investigates the effects of sub-chronic AM6545 administration, revealing its potential as a nootropic compound targeting peripheral CB1 receptors.

Background:
The cannabinoid CB1 receptor plays a significant role in cognitive function. This research builds on previous findings showing that peripheral CB1 receptors influence memory persistence in mice. We now explore how repeated AM6545 exposure impacts cognitive function.

Methods:
Sub-chronic treatment with AM6545 was administered to male and female mice. We conducted transcriptomic analysis, electrophysiological, and biochemical studies to explore the central and peripheral effects of AM6545.

Results:
The results show that AM6545 cognitive enhancement improves memory and executive function, especially in male mice. Synaptic plasticity analysis revealed modulation of hippocampal genes, with AM6545 increasing hippocampal Bdnf and Ngf expression.

Conclusion:
AM6545 enhances memory persistence and synaptic plasticity in mice, suggesting its potential as a novel nootropic targeting peripheral CB1 receptors for cognitive enhancement.

Revolutionary Research on the ECS, cannabinoids and cannabis-based medicine for healthcare from a trusted nonprofit.