doi: 10.3389/fncel.2020.615811. eCollection 2020.
- PMID: 33362478
- PMCID: PMC7755602
- DOI: 10.3389/fncel.2020.615811
Abstract
Cannabinoids have been long studied for their therapeutic properties, particularly for their use in the treatment of pain. As new therapies are sought after to treat conditions of chronic pain, so is a better understanding of the ligands and their target receptors or channels. A recently published cryo-EM structure showed the putative binding location of a well-known cannabinoid ligand, cannabidiol (CBD), in TRPV2, a channel that has been implicated in inflammation and chronic pain. TRPV2, along with TRPV1, TRPV3, TRPV4, TRPA1, and TRPM8 all have the capability to be modulated by cannabinoid ligands and are located in the peripheral nervous system. Here, we analyze the putative CBD binding site in each of these channels and compare structural and sequential information with experimental data.
Keywords: TRP channels, TRPA1, TRPM8, TRPV1, TRPV2, TRPV3, TRPV4, cannabidiol
Copyright © 2020 Muller and Reggio.
Conflict of interest statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
