Cannabidiol (CBD) oil has been gaining popularity as a natural alternative for numerous disease states. CBD is a phytocannabinoid obtained from the Cannabis sativa plant. Unlike its relative tetrahydrocannabinol (THC), CBD does not activate CB1 receptors in the brain and therefore lacks psychotropic effects (1). Instead, this substance is thought to work on the G-protein coupled receptor, endothelial cannabinoid receptor, and serotonin-1A receptors, among others.
Diabetes is the seventh leading cause of death and affects >30 million people in the United States (2). CBD has been investigated, mostly in animal models, for its ability to help treat diabetes. It is theorized that cannabis has desirable effects on hyperglycemia through its anti-inflammatory and antioxidant properties (3). The endocannabinoid system modulates food intake and energy homeostasis by activating cannabinoid receptors. Modulation of these receptors with CBD has the possibility to reduce body weight and A1C in people with diabetes.
In one study using mouse models, CBD was shown to significantly reduce the incidence of diabetes in these mice (4). This was shown by a significant decrease in pancreatic islets production of destructive insulitis and inflammatory cytokine production.
The potential to use CBD as a method to treat diabetes reveals the need for studies and case reports. The following case illustrates the initiation of CBD in a patient with type 2 diabetes.
Case Presentation
A 62-year-old Hispanic obese man (weight 113 kg, BMI 39 kg/m2) with a history of type 2 diabetes for 11 years began taking CBD oil to control his blood glucose in place of insulin degludec. Initiation of this product was independent of his clinician’s recommendation and based on the patient’s personal review of information that suggested CBD was beneficial for people with type 2 diabetes.
As shown in Table 1, the week before the patient’s initiation of CBD, …
