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Canna~Fangled Abstracts

Cannabinoid receptor 2 selective agonists and Alzheimer’s disease: An insight into the therapeutic potentials

By September 6, 2021No Comments
Review
. 2021 Sep 6.

doi: 10.1002/jnr.24933.

Online ahead of print.
Sai Varshini Magham 1, Praveen Thaggikuppe Krishnamurthy 1, Neenu Shaji 1, Lalithkumar Mani 1, Shivaramakrishnan Balasubramanian 1
Affiliations 

Abstract

Endocannabinoid system has been extensively studied in recent decades, particularly the cannabinoid receptors CB1 and CB2, due to their important role in neuroinflammation. Among these, CB2 has gained prominence due to its selective overexpression in glial cells during neuroinflammation. In contrast to CB1 agonists, CB2 agonists have no side effects such as ataxia, hypothermia, euphoria, psychological, or addiction liabilities. CB2 and its selective agonists’ above-mentioned unique properties have become a research focus in neurodegenerative disorders such as Alzheimer’s disease (AD). The review discusses the neuroprotective role of CB receptors, particularly CB2, in AD, as well as the significance and limitations of this research.

 

Keywords: CB1, CNS, endocannabinoid system (ECS), neuroprotection

References

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