doi: 10.4155/ppa-2021-0002. Epub 2021 Jun 11.
- PMID: 34111979
- DOI: 10.4155/ppa-2021-0002
Abstract
The G-protein-coupled cannabinoid receptor type 2 (CB2R) is a key element of the endocannabinoid (EC) system. EC/CB2R signaling has significant therapeutic potential in major pathologies affecting humans such as allergies, neurodegenerative disorders, inflammation or ocular diseases. CB2R agonism exerts anti-inflammatory and tissue protective effects in preclinical animal models of cardiovascular, gastrointestinal, liver, kidney, lung and neurodegenerative disorders. Existing ligands can be subdivided into endocannabinoids, cannabinoid-like and synthetic CB2R ligands that possess various degrees of potency on and selectivity against the cannabinoid receptor type 1. This review is an account of granted CB2R ligand patents from 2010 up to the present, which were surveyed using Derwent Innovation®.
Keywords: G protein-coupled receptor, agonist, cannabinoid receptor type 1, cannabinoid receptor type 2, endocannabinoid system, endocannabinoids
Similar articles
-
Selective Cannabinoid 2 Receptor Agonists as Potential Therapeutic Drugs for the Treatment of Endotoxin-Induced Uveitis.Molecules. 2019 Sep 13;24(18):3338. doi: 10.3390/molecules24183338.PMID: 31540271 Free PMC article.
-
Cannabinoid type-2 receptor agonist, inverse agonist, and anandamide regulation of inflammatory responses in IL-1β stimulated primary human periodontal ligament fibroblasts.J Periodontal Res. 2020 Oct;55(5):762-783. doi: 10.1111/jre.12765. Epub 2020 Jun 20.PMID: 32562275
-
Cannabinoid type 2 receptors mediate a cell type-specific self-inhibition in cortical neurons.Neuropharmacology. 2018 Sep 1;139:217-225. doi: 10.1016/j.neuropharm.2018.07.020. Epub 2018 Jul 17.PMID: 30025920
-
Receptor-dependent and receptor-independent endocannabinoid signaling: a therapeutic target for regulation of cancer growth.Life Sci. 2013 Mar 19;92(8-9):463-6. doi: 10.1016/j.lfs.2012.09.025. Epub 2012 Oct 12.PMID: 23069587 Free PMC article. Review.
-
Cannabinoid Receptors in Diabetic Kidney Disease.Curr Diab Rep. 2018 Feb 5;18(2):9. doi: 10.1007/s11892-018-0975-7.PMID: 29399721 Review.
