Herein, we would like to shortly evaluate the potential of cannabinoids for the treatment of the mentioned diseases.
Published:February 18, 2021DOI:https://doi.org/10.1016/j.survophthal.2021.02.005
With so much interest, we have read the article by Wang et al., 1which has discussed current data about cannabinoids (CBNs) in the field of ophthalmology. Angiogenic dependent diseases such as diabetic retinopathy (DRP) 2and corneal neovascularization (CNV) 3are among the prevalent diseases of the eye. Herein, we would like to shortly evaluate the potential of cannabinoids for the treatment of the mentioned diseases. Angiogenesis has been described as new blood vessel formation which mostly observes in pathological conditions. The endothelial cells (ECs) are the key elements of this process which their proliferation, migration, and tube formation finally leads to the new vessel formation. These steps are dependent on different pro-angiogenic factors and pro-inflammatory cytokines. Vascular endothelial cell growth factor (VEGF) is the main responder of both proliferation and migration of ECs which transcripts by nuclear factor kappa B (NF-κB) stimulated by hypoxia-inducible factor 1 α (HIF-1α). VEGF also affects other angiogenic factors such as matrix metalloproteinases (MMPs) which by the degradation of basement membrane accelerate ECS migration and tube formation. Also, other factors such as basic fibroblast (bFGF), tumor necrosis factor α (TNF-α), and transforming growth factor β (TGF-β), IL-1β, and IL-6 are among the other important factors involved in angiogenesis.
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