Skip to main content
Canna~Fangled Abstracts

Cannabinoids as Prospective Anti-Cancer Drugs: Mechanism of Action in Healthy and Cancer Cells

By November 18, 2022November 19th, 2022No Comments

. 2022 Nov 18.

doi: 10.1007/5584_2022_748.

Online ahead of print.
Özge Boyacıoğlu 1 2, Petek Korkusuz 3
Affiliations 

Abstract

Endogenous and exogenous cannabinoids modulate many physiological and pathological processes by binding classical cannabinoid receptors 1 (CB1) or 2 (CB2) or non-cannabinoid receptors. Cannabinoids are known to exert antiproliferative, apoptotic, anti-migratory and anti-invasive effect on cancer cells by inducing or inhibiting various signaling cascades. In this chapter, we specifically emphasize the latest research works about the alterations in endocannabinoid system (ECS) components in malignancies and cancer cell proliferation, migration, invasion, angiogenesis, autophagy, and death by cannabinoid administration, emphasizing their mechanism of action, and give a future perspective for clinical use.

Keywords: Apoptosis, Autophagy, Cancer, Cannabinoid receptors, Cannabinoids, Cell cycle, Invasion, Migration, Proliferation

References

    1. Abrams DI, Guzman M (2015) Cannabis in cancer care. Clin Pharmacol Ther 97(6):575–586. https://doi.org/10.1002/cpt.108 – DOI
    1. Abuhasira R, Shbiro L, Landschaft Y (2018) Medical use of cannabis and cannabinoids containing products – regulations in Europe and North America. Eur J Intern Med 49:2–6. https://doi.org/10.1016/j.ejim.2018.01.001 – DOI
    1. Abu-Sawwa R, Stehling C (2020) Epidiolex (Cannabidiol) primer: frequently asked questions for patients and caregivers. J Pediatr Pharmacol Ther 25(1):75–77. https://doi.org/10.5863/1551-6776-25.1.75 – DOI
    1. Aizikovich A (2020) Anticancer effect of new cannabinoids derived from Tetrahydrocannabinolic acid on PANC-1 and AsPC-1 human pancreas tumor cells. J Pancreat Cancer 6(1):40–44. https://doi.org/10.1089/pancan.2020.0003 – DOI
    1. Andradas C, Byrne J, Kuchibhotla M, Ancliffe M, Jones AC, Carline B et al (2021) Assessment of Cannabidiol and Δ9-Tetrahydrocannabiol in mouse models of Medulloblastoma and Ependymoma. Cancers 13(2). https://doi.org/10.3390/cancers13020330

Leave a Reply